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一例十二指肠空肠曲肿瘤的罕见病例报告及文献系统综述

An Unusual Case Report of Duodenojejunal Flexure Tumor With a Systematic Review of the Literature.

作者信息

Choudhary Arushi, Patro Shubhransu, Mohapatra Vedavyas, Das Swati, Mishra Akruti, Misra Purusottam, Kossuru Sham Charan, Nath Preetam, Giri Suprabhat

机构信息

General Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

Surgical Gastroenterology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.

出版信息

Cureus. 2024 Dec 22;16(12):e76196. doi: 10.7759/cureus.76196. eCollection 2024 Dec.

DOI:10.7759/cureus.76196
PMID:39840183
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11750052/
Abstract

The small intestine is the longest segment of the gastrointestinal (GI) tract, but cancers in the small intestine are infrequent. The duodenojejunal (DJ) flexure is an uncommon site for tumors, and those located in these sites are difficult to identify and manage properly. Their rarity, along with ambiguous symptoms that can be readily misattributed to milder conditions, results in a delayed diagnosis when the tumors have significantly advanced. We described the case report of a middle-aged woman presenting with features of intestinal obstruction with gastrointestinal bleeding, showing enteroenteric fistula on enteroscopy and cross-sectional imaging, which was later diagnosed as a case of adenocarcinoma treated with surgical resection. We also systematically reviewed the current literature on DJ flexure tumors and compiled data based on various clinical presentations, radiological findings, associated syndromes, management, and outcomes.

摘要

小肠是胃肠道(GI)中最长的一段,但小肠癌并不常见。十二指肠空肠(DJ)曲是肿瘤的罕见部位,位于这些部位的肿瘤难以正确识别和处理。它们的罕见性,以及可能容易被误诊为较轻病症的模糊症状,导致肿瘤显著进展时诊断延迟。我们描述了一例中年女性的病例报告,该患者表现出肠梗阻伴胃肠道出血的特征,在肠镜检查和横断面成像中显示肠肠瘘,后来被诊断为腺癌并接受了手术切除治疗。我们还系统地回顾了关于DJ曲肿瘤的当前文献,并根据各种临床表现、影像学发现、相关综合征、治疗和结果汇编了数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/eb6ebfce37b3/cureus-0016-00000076196-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/e13cffcbc475/cureus-0016-00000076196-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/5614c99a3ec6/cureus-0016-00000076196-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/3a802b8e9a65/cureus-0016-00000076196-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/eb6ebfce37b3/cureus-0016-00000076196-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/e13cffcbc475/cureus-0016-00000076196-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/5614c99a3ec6/cureus-0016-00000076196-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/3a802b8e9a65/cureus-0016-00000076196-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d78d/11750052/eb6ebfce37b3/cureus-0016-00000076196-i04.jpg

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本文引用的文献

1
Expecting the Unexpected: Adenocarcinoma of Duodenojejunal Flexure in a 15-Year-Old.意料之外:一名15岁青少年的十二指肠空肠曲腺癌
Indian J Surg Oncol. 2023 Sep;14(3):749-751. doi: 10.1007/s13193-023-01767-z. Epub 2023 May 9.
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Updates in the diagnosis and management of small-bowel tumors.小肠肿瘤的诊断和治疗进展。
Best Pract Res Clin Gastroenterol. 2023 Jun-Aug;64-65:101860. doi: 10.1016/j.bpg.2023.101860. Epub 2023 Aug 12.
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Incidence, Risk Factors, and Temporal Trends of Small Intestinal Cancer: A Global Analysis of Cancer Registries.
小肠癌的发病率、风险因素和时间趋势:癌症登记处的全球分析。
Gastroenterology. 2023 Sep;165(3):600-612. doi: 10.1053/j.gastro.2023.05.043. Epub 2023 Jun 3.
4
Incidental Uptake of 68Ga-DOTATATE Gastrointestinal Stromal Tumor of Duodenum.十二指肠胃肠道间质瘤意外摄取 68Ga-DOTATATE
Clin Nucl Med. 2022 Mar 1;47(3):e289-e290. doi: 10.1097/RLU.0000000000004036.
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Gastrointestinal stromal tumours: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up.胃肠道间质瘤:ESMO-EURACAN-GENTURIS诊断、治疗及随访临床实践指南
Ann Oncol. 2022 Jan;33(1):20-33. doi: 10.1016/j.annonc.2021.09.005. Epub 2021 Sep 21.
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The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.《PRISMA 2020声明:报告系统评价的更新指南》
Syst Rev. 2021 Mar 29;10(1):89. doi: 10.1186/s13643-021-01626-4.
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Laparoscopic treatment of gastrointestinal stromal tumors located at the duodenojejunal junction.腹腔镜治疗位于十二指肠空肠交界处的胃肠道间质瘤。
SAGE Open Med Case Rep. 2020 Jul 2;8:2050313X20934688. doi: 10.1177/2050313X20934688. eCollection 2020.
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Duodenojejunal intussusception secondary to primary gastrointestinal stromal tumor: A case report.原发性胃肠道间质瘤继发十二指肠空肠套叠:一例报告
Int J Surg Case Rep. 2019;64:15-19. doi: 10.1016/j.ijscr.2019.09.041. Epub 2019 Sep 30.
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Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.小 肠 腺 癌,版 本 1.2020,美 国 国 家 综 合 肿 瘤 网(NCCN)临 床 实 践 指 南 中 医 学 分 册。
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Cancer risk in patients with Peutz-Jeghers syndrome: A retrospective cohort study of 336 cases.黑斑息肉综合征患者的癌症风险:一项对336例病例的回顾性队列研究。
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