Croce Laura, Ruggeri Rosaria Maddalena, Virili Camilla, Cappelli Carlo, Teliti Marsida, Costa Pietro, Chytiris Spyridon, Nicocia Antonio, Coperchini Francesca, Bagaglini Maria Flavia, Magri Flavia, Campenni Alfredo, Rotondi Mario
L Croce, Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
R Ruggeri, Department of Human Pathology and Childhood "G. Barresi", University of Messina, Messina, Italy.
Eur Thyroid J. 2025 Jan 1;14(1). doi: 10.1530/ETJ-24-0190.
The prevalence of Thyroid-Cancer (TC) has increased worldwide and an association with metabolic and cardio-vascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid related imaging for other clinical conditions. Our aim was to assess the prevalence of Thyroid-Related (TD) versus Incidental (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities.
we performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy.
Consecutive patients with TC Measurements: data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardio-metabolic comorbidities and non-thyroid cancer.
among the 327 enrolled subjects the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones, they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extra-thyroidal extension, lymph-node metastases, AJCC Staging or ATA Risk stratification.
biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features.
甲状腺癌（TC）在全球范围内的患病率呈上升趋势，且有报道称其与代谢和心血管疾病有关。此外，目前越来越多的患者是在因其他临床情况进行非甲状腺相关成像检查时偶然被诊断出甲状腺癌的。我们的目的是评估导致甲状腺癌诊断的甲状腺相关（TD）与偶然（ID）术前原因的患病率，并比较两组患者在临床特征、甲状腺癌出现时的大小和严重程度以及非甲状腺癌和心血管/代谢合并症发生率方面的差异。
我们在意大利三个大型甲状腺疾病医院中心（帕维亚、拉蒂纳和墨西拿）进行了一项回顾性队列研究。
连续纳入的甲状腺癌患者测量指标：导致甲状腺癌诊断的术前原因、年龄、性别、体重指数、心血管代谢合并症和非甲状腺癌的情况。
在327名纳入研究的受试者中，262名（80.1%，TD组）因甲状腺相关原因被诊断为甲状腺癌，65名（19.9%，ID组）为偶然诊断。ID组患者男性比例更高，年龄显著更大，体重指数也高于TD组，他们的非甲状腺癌和心血管/代谢合并症发生率更高。在甲状腺癌组织学类型、癌灶大小、甲状腺外侵犯、淋巴结转移、美国癌症联合委员会（AJCC）分期或美国甲状腺协会（ATA）风险分层方面，未观察到显著差异。
TD组和ID组甲状腺癌的生物学特征相似，但两组患者的临床特征存在显著差异。
