Zhao Qiuyue, Maimaitiaili Subinuer, Bi Yan, Li Ming, Li Xin, Li Qian, Shen Xinyi, Wu Min, Fu Linqing, Zhu Zhengyang, Zhang Xin, Chen Jiu, Hu Anning, Zhang Zhou, Zhang Wen, Zhang Bing
Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing City, Jiangsu Province, China.
Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing City, Jiangsu Province, China.
J Diabetes. 2025 Jan;17(1):e70052. doi: 10.1111/1753-0407.70052.
Iron is one of the most important elements in brain that may has a direct impact on the stability of central nervous system. The current study devoted to explore the alterations of iron distribution across the whole brain in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI).
The quantitative susceptibility mapping (QSM) technique was used to quantify the intracranial iron content of 74 T2DM patients with MCI and 86 T2DM patients with normal cognition (NC). The group comparison was performed by a voxel-based analysis. Then we evaluated the relationships between cognitive indicators and magnetic susceptibility value (MSV) measured by QSM of the significant brain areas, which were set as the regions of interest (ROIs). In addition, we analyzed the moderation effects of grey matter volume (GMV) of the related brain areas and several metabolic and cerebrovascular factors on the associations between MSV of ROIs and cognitive characteristics.
T2DM patients with MCI exhibited a lower MSV in the right middle temporal gyrus (MTG) compared to NC group. And in the MCI group, there were significantly negative correlations between MSV of the right MTG and several memory indexes. Furthermore, the moderation effects of GMV of the whole brain and the bilateral MTG on the relationship between MSV of the right MTG and scores of list recognition were significant.
T2DM patients with MCI had a temporary decreased iron content in the right MTG, which may partially compensate for cognitive impairment.
The study was registered at Clinicaltrials.gov (NCT02738671).
铁是大脑中最重要的元素之一，可能对中枢神经系统的稳定性产生直接影响。当前研究致力于探索轻度认知障碍（MCI）的2型糖尿病（T2DM）患者全脑铁分布的变化。
采用定量磁化率成像（QSM）技术对74例患有MCI的T2DM患者和86例认知正常（NC）的T2DM患者的颅内铁含量进行量化。通过基于体素的分析进行组间比较。然后，我们评估了显著脑区的认知指标与通过QSM测量的磁化率值（MSV）之间的关系，这些脑区被设定为感兴趣区域（ROIs）。此外，我们分析了相关脑区的灰质体积（GMV）以及几种代谢和脑血管因素对ROIs的MSV与认知特征之间关联的调节作用。
与NC组相比，患有MCI的T2DM患者右侧颞中回（MTG）的MSV较低。并且在MCI组中，右侧MTG的MSV与几个记忆指标之间存在显著的负相关。此外，全脑和双侧MTG的GMV对右侧MTG的MSV与列表识别得分之间关系的调节作用显著。
患有MCI的T2DM患者右侧MTG的铁含量暂时降低，这可能部分补偿了认知障碍。
该研究已在Clinicaltrials.gov（NCT02738671）注册。
