Wal Pranay, Tarannum Tarannum, Baldaniya Lalji, Kaur Kiranjeet, Singh Priyanka, Aziz Namra, Singh Komal, Gasmi Amin
PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH-19, Kanpur, UP, 209305, India.
University of Alberta, Edmonton, Alberta, Canada.
Curr Protein Pept Sci. 2025;26(6):407-421. doi: 10.2174/0113892037340795241202044932.
Diabetic nephropathy is characterized by elevated oxidative stress and chronic inflammation in the kidneys. A class of proteins called sirtuins is well-known to be important for a number of cellular functions, such as metabolism, stress tolerance, and ageing. Among them, SIRT1 is associated with the progression of diabetic nephropathy, a dangerous kidney-related consequence of diabetes mellitus. Thus, this study aims to examine the function and pathways of sirtuin that are responsible for the progression of this disease.
Publications considered from the standard databases like Pubmed-Medline, Google Scholar, and Scopus using standard keywords, "Sirtuin," Signalling pathway", and "Diabetic Nephropathy" well described the actual knowledge on the scientific literature indicating patient susceptibility to kidney disease that is influenced by sirtuin-1 gene variants.
The research results imply that sirtuins offer enormous promise as cutting-edge therapeutic targets for kidney disease prevention and management. Renal fibrosis, metabolic disorders, renal impairment, and a possible regulation mechanism all probably entail blocking inflammation through various signalling pathways.
A comprehensive understanding of the fundamental pathophysiological pathways targeting sirtuin is essential as a diagnostic tool. For the treatment of diabetic nephropathy, researchers are developing therapeutic techniques to target biological roles and functions of different types of sirtuin, processes, and signalling pathways.
糖尿病肾病的特征是肾脏中的氧化应激升高和慢性炎症。一类名为沉默调节蛋白的蛋白质因对多种细胞功能（如代谢、应激耐受和衰老）很重要而广为人知。其中，SIRT1与糖尿病肾病的进展相关，糖尿病肾病是糖尿病的一种危险的肾脏相关后果。因此，本研究旨在研究负责该疾病进展的沉默调节蛋白的功能和途径。
使用标准关键词“Sirtuin”“信号通路”和“糖尿病肾病”，从标准数据库如Pubmed-Medline、谷歌学术和Scopus中检索的出版物很好地描述了科学文献中关于患者对受沉默调节蛋白1基因变异影响的肾病易感性的实际知识。
研究结果表明，沉默调节蛋白作为预防和管理肾病的前沿治疗靶点具有巨大潜力。肾纤维化、代谢紊乱、肾功能损害以及一种可能的调节机制可能都需要通过各种信号通路来阻断炎症。
全面了解针对沉默调节蛋白的基本病理生理途径作为一种诊断工具至关重要。对于糖尿病肾病的治疗，研究人员正在开发针对不同类型沉默调节蛋白的生物学作用和功能、过程及信号通路的治疗技术。
