Chaurasia Akhilanand, Brigi Carel, Daghrery Arwa, Asa'ad Farah, Spirito Francesca, Hasuike Akira, González-Alva Patricia, Kojic Dave D, Ünsal Revan Birke Koca, Sivaramakrishnan Gowri
Department of Oral Medicine and Radiology, King George's Medical University, Lucknow, India.
Department of Oral Diagnosis, Research Institute for Medical and Health Sciences, University of Sharjah, Sharjah, UAE.
Oral Dis. 2025 Jan 23. doi: 10.1111/odi.15265.
Tumour-associated macrophages (TAMs) are crucial in the progression and treatment response of oral squamous cell carcinoma (OSCC). TAMs infiltrate OSCC, adopting an M2-like phenotype that promotes tumour growth, metastasis and immune suppression. The current narrative review explored the roles of TAMs in OSCC, focusing on their impact on the tumour microenvironment, invasion, metastasis, angiogenesis, immunosuppression and potential therapeutic targeting.
A comprehensive analysis of the current literature on TAMs in OSCC was conducted. Specifically, we evaluated the biological functions of TAMs, their interactions within the tumour microenvironment, and their influence on disease progression and treatment outcomes.
TAMs contribute to OSCC progression by secreting cytokines, such as IL-10 and TGF-β, that inhibit effector immune cells. They facilitate angiogenesis, extracellular matrix remodelling and the epithelial-mesenchymal transition, which are essential for tumour invasion and metastasis. TAMs support cancer stem cells and recruit regulatory T cells and myeloid-derived suppressor cells, enhancing resistance to therapies. Their presence correlates with advanced OSCC stages, lymph node metastasis and poor prognosis.
TAMs regulate OSCC progression and therapy resistance. Reprogramming them to an M1-like phenotype or depleting them enhances treatments. Understanding TAM-OSCC interactions is crucial for developing interventions against their tumour-promoting functions and restoring anti-tumour immunity.
肿瘤相关巨噬细胞（TAMs）在口腔鳞状细胞癌（OSCC）的进展和治疗反应中起关键作用。TAMs浸润OSCC，呈现类似M2的表型，促进肿瘤生长、转移和免疫抑制。本叙述性综述探讨了TAMs在OSCC中的作用，重点关注它们对肿瘤微环境、侵袭、转移、血管生成、免疫抑制和潜在治疗靶点的影响。
对当前关于OSCC中TAMs的文献进行了全面分析。具体而言，我们评估了TAMs的生物学功能、它们在肿瘤微环境中的相互作用以及它们对疾病进展和治疗结果的影响。
TAMs通过分泌抑制效应免疫细胞的细胞因子（如IL-10和TGF-β）来促进OSCC进展。它们促进血管生成、细胞外基质重塑和上皮-间质转化，这些对于肿瘤侵袭和转移至关重要。TAMs支持癌症干细胞并募集调节性T细胞和髓源性抑制细胞，增强对治疗的抗性。它们的存在与晚期OSCC阶段、淋巴结转移和不良预后相关。
TAMs调节OSCC进展和治疗抗性。将它们重编程为类似M1的表型或耗尽它们可增强治疗效果。了解TAM-OSCC相互作用对于开发针对其促肿瘤功能的干预措施和恢复抗肿瘤免疫力至关重要。
