使用MASK空气净化器的变应性鼻炎及其对哮喘的影响（ARIA）分级

Allergic Rhinitis and its Impact on Asthma (ARIA) Classes in MASK-air Users.

作者信息

Sousa-Pinto B, Savouré M, Vieira R J, Amaral R, Czarlewski W, Bedbrook A, Valiulis A, Kvedariene V, Brussino L, Gemicioglu B, Haahtela T, Klimek L, Kraxner H, Larenas-Linnemann D E, Pfaar O, Regateiro F S, Samolinski B, Taborda-Barata L, Toppila-Salmi S, Ventura M T, Ansotegui I J, Braido F, Canonica G W, Cecchi L, Cruz A A, Devillier P, Fokkens W J, Gil-Mata S, Giuliano A Fm, Ivancevich J C, Kuna P, Kupczyk M, Louis G, Louis R, Makris M, Morais-Almeida M, Mullol J, Nadif R, Niedoszytko M, Okamoto Y, Ollert M, Papadopoulos N G, Patella V, Pawankar R, Pereira A M, Pétré B, Pham-Thi N, Roche N, Rouadi P W, Sastre J, Scichilone N, Sheikh A, Sova M, Todo-Bom A, Yorgancioglu A, Zidarn M, Anto J M, Zuberbier T, Fonseca J A, Bousquet J

机构信息

MEDCIDS - Department of Community Medicine, Information and Health Decision Sciences; Faculty of Medicine, University of Porto, Porto, Portugal.

CINTESIS@RISE- Health Research Network, Faculty of Medicine, University of Porto, Porto, Portugal.

出版信息

J Investig Allergol Clin Immunol. 2025 Jan 23:0. doi: 10.18176/jiaci.1047.

DOI:10.18176/jiaci.1047

PMID:39846812

Abstract

BACKGROUND AND OBJECTIVES

The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines classify rhinitis as "intermittent" or "persistent" and "mild" or "moderate-severe". To assess ARIA classes in a real-world study in terms of phenotypic differences and their association with asthma.

METHODS

We performed a cross-sectional real-world study based on users of the MASK-air® app who reported data for at least 3 different months. We assessed the frequency of users according to the ARIA classes and compared these classes in terms of rhinitis symptoms, use of comedication, frequency of comorbid asthma, and the association between comorbid asthma and rhinitis control.

RESULTS

A total of 2273 users (180 796 days) were assessed. Most users had moderate-severe rhinitis (n=2003; 88.1%) and persistent rhinitis (n=1144; 50.3%). The frequency of patients with probable asthma was 35.7% (95%CI, 34.5%-37.0%) for intermittent rhinitis and 48.5% (95%CI, 47.1%-49.9%) for persistent rhinitis. The maximum values on the visual analog scale (VAS) for rhinitis symptoms and the combined symptom medication score were lower in patients with mild rhinitis than in those with moderate-severe rhinitis (irrespective of whether they had persistent or intermittent rhinitis). In most ARIA classes, VAS nose and VAS eye and rhinitis comedication were more frequent in patients with rhinitis+asthma than in those with rhinitis alone.

CONCLUSION

This study suggests that the presence of asthma is more closely related to persistence of rhinitis than to severity and that the presence of comorbid asthma may be associated with poorer control of rhinitis across the different ARIA classes.

摘要

背景与目的

变应性鼻炎及其对哮喘的影响（ARIA）指南将鼻炎分为“间歇性”或“持续性”以及“轻度”或“中重度”。在一项真实世界研究中，根据表型差异及其与哮喘的关联来评估ARIA分类。

方法

我们基于报告了至少3个不同月份数据的MASK-air®应用程序用户进行了一项横断面真实世界研究。我们根据ARIA分类评估用户频率，并在鼻炎症状、联合用药情况、合并哮喘的频率以及合并哮喘与鼻炎控制之间的关联方面对这些分类进行比较。

结果

共评估了2273名用户（180796天）。大多数用户患有中重度鼻炎（n = 2003；88.1%）和持续性鼻炎（n = 1144；50.3%）。间歇性鼻炎患者中可能患有哮喘的频率为35.7%（95%CI，34.5% - 37.0%），持续性鼻炎患者中为48.5%（95%CI，47.1% - 49.9%）。轻度鼻炎患者鼻炎症状的视觉模拟量表（VAS）最大值和综合症状药物评分低于中重度鼻炎患者（无论其为持续性还是间歇性鼻炎）。在大多数ARIA分类中，鼻炎合并哮喘患者的VAS鼻部、VAS眼部和鼻炎联合用药情况比单纯鼻炎患者更频繁。