Jeong Ga Hee, Kim Ki Chan, Lee Ji Hyun
Department of Medical Sciences, Graduate School of The Catholic University of Korea, Seoul, #222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, #222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Cells. 2025 Jan 9;14(2):83. doi: 10.3390/cells14020083.
Cannabinoid compounds have potential as treatments for a variety of conditions, with cannabigerol (CBG) being known for its anti-inflammatory properties. In this study, we investigated the effects of CBG in a cellular model of 1-chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis (AD). In the cellular model, we confirmed the cytotoxicity of CBG and downregulated the expression of inflammatory markers , , , and ( < 0.001). In the mouse model, clinical, histological, and immunological changes were analyzed. The results showed that CBG improved dermatitis severity score, epidermal thickness, and mast cell count and reduced inflammatory cytokines (, , , , , , , , and ) by qRT-PCR ( < 0.001). Western blot results showed modulated changes in JAK1, JAK2, TYK2, STAT1, STAT2, STAT3, p-STAT3, STAT6, and p-STAT6 ( < 0.05). Subsequently, p-IκBα, NF-κB, and p-NF-κB signaling factors were also reduced ( < 0.05), with corresponding changes in skin barrier factors. The results of this study indicate that CBG effectively alleviates AD-like symptoms and suggest the potential of CBG as a therapeutic agent.
大麻素化合物有潜力用于治疗多种病症，其中大麻二醇（CBG）以其抗炎特性而闻名。在本研究中，我们在1-氯-2,4-二硝基苯（DNCB）诱导的特应性皮炎（AD）细胞模型中研究了CBG的作用。在细胞模型中，我们证实了CBG的细胞毒性，并下调了炎症标志物 、 、 和 的表达（<0.001）。在小鼠模型中，分析了临床、组织学和免疫学变化。结果表明，通过qRT-PCR检测，CBG改善了皮炎严重程度评分、表皮厚度和肥大细胞计数，并降低了炎症细胞因子（ 、 、 、 、 、 、 、 和 ）（<0.001）。蛋白质免疫印迹结果显示JAK1、JAK2、TYK2、STAT1、STAT2、STAT3、p-STAT3、STAT6和p-STAT6有调节性变化（<0.05）。随后，p-IκBα、NF-κB和p-NF-κB信号因子也减少（<0.05），皮肤屏障因子有相应变化。本研究结果表明，CBG可有效缓解类AD症状，并提示CBG作为治疗剂的潜力。
