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通过开发预防性疫苗平台探索未来大流行防范以及国际组织在全球卫生危机中的关键作用。

Exploring Future Pandemic Preparedness Through the Development of Preventive Vaccine Platforms and the Key Roles of International Organizations in a Global Health Crisis.

作者信息

Jeon Jihee, Kim Eunyoung

机构信息

Pharmaceutical Regulatory Affairs, Department of Pharmaceutical Industry, Graduate School, Chung-Ang University, Seoul 06974, Republic of Korea.

Central Research Center of Epigenome Based Platform and Its Application for Drug Development, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea.

出版信息

Vaccines (Basel). 2025 Jan 10;13(1):56. doi: 10.3390/vaccines13010056.


DOI:10.3390/vaccines13010056
PMID:39852835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768803/
Abstract

The emergence of more than 40 new infectious diseases since the 1980s has emerged as a serious global health concern, many of which are zoonotic. In response, many international organizations, including the US Centers for Disease Control and Prevention (CDC), the World Health Organization (WHO), and the European Center for Disease Prevention and Control (ECDC), have developed strategies to combat these health threats. The need for rapid vaccine development has been highlighted by Coronavirus disease 2019 (COVID-19), and mRNA technology has shown promise as a platform. While the acceleration of vaccine development has been successful, concerns have been raised about the technical limits, safety, supply, and distribution of vaccines. This study analyzes the status of vaccine platform development in global pandemics and explores ways to respond to future pandemic crises through an overview of the roles of international organizations and their support programs. It examines the key roles and partnerships of international organizations such as the World Health Organization (WHO), vaccine research and development expertise of the Coalition for Epidemic Preparedness Innovations (CEPI), control of the vaccine supply chain and distribution by the Global Alliance for Vaccines and Immunization (GAVI), and technology transfer capabilities of the International Vaccine Institute (IVI) in supporting the development, production, and supply of vaccine platform technologies for pandemic priority diseases announced by WHO and CEPI and analyzes their vaccine support programs and policies to identify effective ways to rapidly respond to future pandemics caused by emerging infectious diseases. : This study focused on vaccine platform technology and the key roles of international organizations in the pandemic crisis. Literature data on vaccine platform development was collected, compared, and analyzed through national and international literature data search sites, referring to articles, journals, research reports, publications, books, guidelines, clinical trial data, and related reports. In addition, the websites of international vaccine support organizations, such as WHO, CEPI, GAVI, and IVI, were used to examine vaccine support projects, initiatives, and collaborations through literature reviews and case study methods. : The COVID-19 pandemic brought focus on the necessity for developing innovative vaccine platforms. Despite initial concerns, the swift integration of cutting-edge development technologies, mass production capabilities, and global collaboration have made messenger RNA (mRNA) vaccines a game-changing technology. As a result of the successful application of novel vaccine platforms, it is important to address the remaining challenges, including technical limits, safety concerns, and equitable global distribution. To achieve this, it is essential to review the regulatory, policy, and support initiatives that have been implemented in response to the COVID-19 pandemic, with particular emphasis on the key stages of vaccine development, production, and distribution, to prepare for future pandemics. An analysis of the status of vaccine development for priority pandemic diseases implies the need for balanced vaccine platform development. Also, international organizations such as WHO, CEPI, GAVI, and IVI play key roles in pandemic preparedness and the development and distribution of preventive vaccines. These organizations collaborated to improve accessibility to vaccines, strengthen the global response to infectious diseases, and address global health issues. The COVID-19 pandemic response demonstrates how the synergistic collaboration of WHO's standardized guidelines, CEPI's vaccine research and development expertise, GAVI's control of the vaccine supply chain and distribution, and IVI's technology transfer capabilities can be united to create a successful process for vaccine development and distribution. : In preparation for future pandemics, a balanced vaccine platform development is essential. It should include a balanced investment in both novel technologies such as mRNA and viral vector-based vaccines and traditional platforms. The goal is to develop vaccine platform technologies that can be applied to emerging infectious diseases efficiently and increase manufacturing and distribution capabilities for future pandemics. Moreover, international vaccine support organizations should play key roles in setting the direction of global networking and preparing for international vaccine support programs to address the limitations of previous pandemic responses. As a result, by transforming future pandemic threats from unpredictable crises to surmountable challenges, it is expected to strengthen global health systems and reduce the social and economic burden of emerging infectious diseases in the long term.

摘要

自20世纪80年代以来,40多种新出现的传染病已成为严重的全球卫生问题,其中许多是人畜共患病。作为回应,包括美国疾病控制与预防中心(CDC)、世界卫生组织(WHO)和欧洲疾病预防与控制中心(ECDC)在内的许多国际组织已制定战略来应对这些健康威胁。2019冠状病毒病(COVID-19)凸显了快速开发疫苗的必要性,而信使核糖核酸(mRNA)技术已显示出作为一个平台的潜力。虽然疫苗开发的加速取得了成功,但人们对疫苗的技术限制、安全性、供应和分配也提出了担忧。本研究通过概述国际组织的作用及其支持项目,分析了全球大流行中疫苗平台开发的现状,并探索应对未来大流行危机的方法。它考察了世界卫生组织(WHO)等国际组织的关键作用和伙伴关系、流行病防范创新联盟(CEPI)的疫苗研发专业知识、全球疫苗免疫联盟(GAVI)对疫苗供应链和分配的控制,以及国际疫苗研究所(IVI)在支持开发、生产和供应WHO和CEPI宣布的大流行重点疾病疫苗平台技术方面的技术转让能力,并分析了它们的疫苗支持项目和政策,以确定快速应对由新出现的传染病引起的未来大流行的有效方法。:本研究聚焦于疫苗平台技术以及国际组织在大流行危机中的关键作用。通过国家和国际文献数据搜索网站收集、比较和分析了关于疫苗平台开发的文献数据,参考了文章、期刊、研究报告、出版物、书籍、指南、临床试验数据及相关报告。此外,还利用WHO、CEPI、GAVI和IVI等国际疫苗支持组织的网站,通过文献综述和案例研究方法考察疫苗支持项目、倡议和合作。:COVID-19大流行使人们关注开发创新疫苗平台的必要性。尽管最初存在担忧,但前沿开发技术、大规模生产能力和全球合作的迅速整合使信使核糖核酸(mRNA)疫苗成为一项改变游戏规则的技术。由于新型疫苗平台的成功应用,应对包括技术限制、安全担忧和全球公平分配在内的剩余挑战至关重要。要实现这一目标,必须审查为应对COVID-19大流行而实施的监管、政策和支持举措,尤其要关注疫苗开发、生产和分配的关键阶段,为未来大流行做好准备。对大流行重点疾病疫苗开发现状的分析表明需要平衡疫苗平台的开发。此外,WHO、CEPI、GAVI和IVI等国际组织在大流行防范以及预防性疫苗的开发和分配中发挥着关键作用。这些组织合作以提高疫苗的可及性、加强全球对传染病的应对并解决全球卫生问题。COVID-19大流行应对行动展示了WHO的标准化指南、CEPI的疫苗研发专业知识、GAVI对疫苗供应链和分配的控制以及IVI的技术转让能力如何协同合作,创造一个成功的疫苗开发和分配过程。:为应对未来大流行,平衡的疫苗平台开发至关重要。这应包括对mRNA和基于病毒载体的疫苗等新技术以及传统平台进行平衡投资。目标是开发能够有效应用于新出现传染病的疫苗平台技术,并提高未来大流行时的生产和分配能力。此外,国际疫苗支持组织应在设定全球网络方向和筹备国际疫苗支持项目以解决以往大流行应对措施的局限性方面发挥关键作用。因此,通过将未来大流行威胁从不可预测的危机转变为可克服的挑战,有望加强全球卫生系统并长期减轻新出现传染病的社会和经济负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb64/11768803/1b32aa4b8676/vaccines-13-00056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb64/11768803/7897c056359b/vaccines-13-00056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb64/11768803/1b32aa4b8676/vaccines-13-00056-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb64/11768803/7897c056359b/vaccines-13-00056-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb64/11768803/1b32aa4b8676/vaccines-13-00056-g002.jpg

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