Li Ningxin, Li Mingzhu, Jin Shengbo, Yu Jun, Wei Hongzhe, Wang Wenping, Ma Siyao, Jiang Yuxin, Liu Qian, Yao Huini
China Medical University, Shenyang, China.
Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Sheng Yang, China.
Animal Model Exp Med. 2025 Jul;8(7):1206-1214. doi: 10.1002/ame2.12548. Epub 2025 Jan 23.
Cisplatin chemotherapy has been used as the main treatment for different types of cancer. However, cisplatin chemotherapy-induced peripheral neuropathic pain (CIPNP) seriously affects the treatment process and quality of life of patients. In addition, it impacts the underlying mechanism and prevention and treatment strategies, indicating that drug selection and efficacy evaluation need to be further investigated. Furthermore, an animal model that is more consistent with the pathological mechanism needs to be developed. In this study, we describe and discuss the methods of developing and detecting CIPNP models in rats and mice induced by cisplatin chemotherapy. The aim was to improve the modeling rate and develop animal models that are more consistent with the developmental pattern of the disease. In addition, the study provides ideal reference animal models for clinical research and drug discovery and development.
顺铂化疗一直被用作不同类型癌症的主要治疗方法。然而，顺铂化疗诱导的周围神经性疼痛（CIPNP）严重影响患者的治疗过程和生活质量。此外，它还影响其潜在机制以及预防和治疗策略，这表明药物选择和疗效评估需要进一步研究。此外，需要开发一种与病理机制更一致的动物模型。在本研究中，我们描述并讨论了在大鼠和小鼠中建立和检测顺铂化疗诱导的CIPNP模型的方法。目的是提高建模成功率，并开发与疾病发展模式更一致的动物模型。此外，该研究为临床研究以及药物发现和开发提供了理想的参考动物模型。
