Kumagai K
Gan To Kagaku Ryoho. 1985 Mar;12(3 Pt 2):726-33.
This article focuses on the roles of natural killer (NK) cells and lymphokine-activated killer (LAK) cells in immune surveillance against malignant tumors. NK cells have a natural and also rapidly activatable ability to lyse a variety of tumor cell lines. There is considerable evidence for the ability of NK cells to eliminate metastatic tumor cells and thereby resist tumor spread. There is also a correlation between increased tumor incidence (primarily lymphoma) and depressed NK activity. Therefore, NK cells appear to contribute to antitumor resistance, especially against the microevolution of tumor cells and metastasis. LAK cells, which can be induced by a lymphokine, interleukin 2, in a subset of NK cells, express cytotoxic activity toward an extensive spectrum of histologically distinct fresh autologous tumor cells. Fresh tumor cells resistant to lysis by NK cells are extremely sensitive to lysis by LAK cells. Although the biological role of these cells is presently unknown, their characteristics also point toward an important function in immune surveillance.
本文重点关注自然杀伤（NK）细胞和淋巴因子激活的杀伤（LAK）细胞在针对恶性肿瘤的免疫监视中的作用。NK细胞具有天然且可快速激活的能力，能裂解多种肿瘤细胞系。有大量证据表明NK细胞有能力清除转移性肿瘤细胞，从而抵抗肿瘤扩散。肿瘤发病率增加（主要是淋巴瘤）与NK活性降低之间也存在关联。因此，NK细胞似乎有助于抗肿瘤抗性，尤其是抵抗肿瘤细胞的微进化和转移。LAK细胞可由淋巴因子白细胞介素2在一部分NK细胞中诱导产生，对多种组织学上不同的新鲜自体肿瘤细胞表现出细胞毒性活性。对NK细胞裂解具有抗性的新鲜肿瘤细胞对LAK细胞的裂解极为敏感。尽管这些细胞的生物学作用目前尚不清楚，但其特性也表明它们在免疫监视中具有重要功能。
