Foley Jayne Marie, Kwiatkowski Carol F, Rochester Johanna R, Neveux Iva, Dabe Shaun, Lathrop Michael Kupec, Daza Eric J, Grzymski Joseph J, Greenfield Ben K, Hua Jenna
Million Marker Wellness, Inc., Berkeley, CA 94704, USA.
Healthy Nevada Project, Renown Health, Reno, NV 89557, USA.
Int J Environ Res Public Health. 2025 Jan 13;22(1):99. doi: 10.3390/ijerph22010099.
Daily-use products, including personal care products, household products, and dietary supplements, often contain ingredients that raise concerns regarding harmful chemical exposure. Endocrine-disrupting chemicals (EDCs) found in daily-use products are associated with numerous adverse health effects.
This pilot study explores the relationship between concentrations of EDCs in urine samples and products used 24 h prior to sample collection, and ingredients of concern in those products, in 140 adults of reproductive age in Northern Nevada.
Having higher numbers of products and ingredients of concern, especially in the personal care category, was associated with higher levels of mono-(-ethyl-5-carboxypentyl) phthalate (MECPP). Similarly, taking more supplements was associated with higher levels of methylparaben (MePB). In contrast, using household products with more ingredients of concern was associated with lower levels of monobutyl phthalate (MBP). Generally, women used more products, were exposed to more ingredients of concern and had higher urinary metabolites than men. Participants who rated themselves as being in poor/fair health were exposed to more personal care and supplement ingredients of concern than those in better health. Interestingly, those in excellent health also took supplements with more ingredients of concern.
Greater product use and more ingredients of concern are associated with urinary metabolites of known EDCs and self-ratings of poor health. Women and people who take supplements are at greater risk, and even people who consider themselves to be healthy can be highly exposed. More education among the general public is needed to make people aware of the presence of these chemicals in their everyday products so they can make efforts to avoid them.
包括个人护理产品、家用产品和膳食补充剂在内的日常用品,通常含有引发有害化学物质暴露担忧的成分。日常用品中发现的内分泌干扰化学物质(EDC)与众多不良健康影响相关。
这项初步研究探讨了内华达州北部140名育龄成年人尿液样本中EDC浓度与样本采集前24小时使用的产品及其关注成分之间的关系。
拥有更多数量的关注产品和成分,尤其是在个人护理类别中,与较高水平的单(-乙基-5-羧基戊基)邻苯二甲酸酯(MECPP)相关。同样,服用更多补充剂与较高水平的对羟基苯甲酸甲酯(MePB)相关。相比之下,使用含有更多关注成分的家用产品与较低水平的单丁基邻苯二甲酸酯(MBP)相关。总体而言,女性使用的产品更多,接触到的关注成分更多,尿液代谢物水平也高于男性。将自己健康状况评为差/一般的参与者比健康状况较好的参与者接触到更多个人护理和补充剂关注成分。有趣的是,健康状况极佳的人也服用了含有更多关注成分的补充剂。
更多的产品使用和更多的关注成分与已知EDC的尿液代谢物以及健康状况差的自我评估相关。女性和服用补充剂的人风险更大,甚至自认为健康的人也可能有高暴露风险。需要对公众进行更多教育,使人们意识到日常用品中存在这些化学物质,以便他们能够努力避免接触。