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甲状腺疾病中的肥胖治疗应何时开始?

When Should the Treatment of Obesity in Thyroid Disease Begin?

作者信息

Sutkowska Edyta, Kisiel Michał, Zubkiewicz-Kucharska Agnieszka

机构信息

Department of Clinical Physiotherapy and Rehabilitation, Faculty of Physiotherapy, Wroclaw Medical University, 50-367 Wroclaw, Poland.

Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland.

出版信息

Biomedicines. 2025 Jan 10;13(1):157. doi: 10.3390/biomedicines13010157.

DOI:10.3390/biomedicines13010157
PMID:39857741
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11760466/
Abstract

Obesity often coexists with thyroid diseases, and the prevalence of these disorders has been on the rise for years. While hypothyroidism can contribute to excess fat tissue, the relationship between Body Mass Index (BMI) and thyroid function hormones is bidirectional. Research confirms that fat tissue reduction can positively impact thyroid function. Thus, delaying the initiation of therapies beyond substitution treatment to achieve optimal weight reduction in individuals with thyroid dysfunction seems unwarranted. The authors summarize current knowledge on this topic in the article.

摘要

肥胖常与甲状腺疾病并存,且这些疾病的患病率多年来一直在上升。虽然甲状腺功能减退会导致脂肪组织过多,但体重指数(BMI)与甲状腺功能激素之间的关系是双向的。研究证实,减少脂肪组织对甲状腺功能有积极影响。因此,对于甲状腺功能障碍患者,推迟开始替代治疗以外的疗法以实现最佳体重减轻似乎没有必要。作者在文章中总结了关于这一主题的现有知识。

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JAMA Intern Med. 2025 Mar 1;185(3):255-256. doi: 10.1001/jamainternmed.2024.6450.
2
Impaired Sensitivity to Thyroid Hormones is Associated with Central Obesity in Euthyroid Type 2 Diabetes Mellitus Patients with Overweight and Obesity.甲状腺激素敏感性受损与超重和肥胖的甲状腺功能正常的2型糖尿病患者的中心性肥胖有关。
Diabetes Metab Syndr Obes. 2024 Sep 11;17:3379-3396. doi: 10.2147/DMSO.S472550. eCollection 2024.
3
The Effect of Mediterranean Diet on Thyroid Gland Activity.地中海饮食对甲状腺活动的影响。
Int J Mol Sci. 2024 May 28;25(11):5874. doi: 10.3390/ijms25115874.
4
Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study.胰高血糖素样肽 1 受体激动剂的使用与甲状腺癌风险:斯堪的纳维亚队列研究。
BMJ. 2024 Apr 10;385:e078225. doi: 10.1136/bmj-2023-078225.
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5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study.英国减肥维持持续支持随机糖尿病缓解临床试验(DiRECT)的 5 年随访:一项扩展研究。
Lancet Diabetes Endocrinol. 2024 Apr;12(4):233-246. doi: 10.1016/S2213-8587(23)00385-6. Epub 2024 Feb 26.
6
Causal association between obesity and hypothyroidism: a two-sample bidirectional Mendelian randomization study.肥胖与甲状腺功能减退症之间的因果关系:两样本双向孟德尔随机化研究。
Front Endocrinol (Lausanne). 2024 Jan 8;14:1287463. doi: 10.3389/fendo.2023.1287463. eCollection 2023.
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Effect of physical exercise in people with hypothyroidism: systematic review and meta-analysis.运动对甲状腺功能减退症患者的影响:系统评价和荟萃分析。
Scand J Clin Lab Invest. 2023 Dec;83(8):523-532. doi: 10.1080/00365513.2023.2286651. Epub 2024 Jan 24.
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