Yi Min-Hee, Lee Jinkyung, Moon Subin, So EunA, Bang Geonhyeok, Moon Kyung-Sub, Lee Kyung-Hwa
Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasun 58128, Jeollanam-do, Republic of Korea.
Biomedical Sciences Graduate Program (BMSGP), Chonnam National University, Hwasun 58128, Jeollanam-do, Republic of Korea.
Biomedicines. 2025 Jan 16;13(1):216. doi: 10.3390/biomedicines13010216.
: Brain cancers represent a formidable oncological challenge characterized by their aggressive nature and resistance to conventional therapeutic interventions. The tumor microenvironment has emerged as a critical determinant of tumor progression and treatment efficacy. Within this complex ecosystem, microglia and macrophages play fundamental roles, forming intricate networks with peripheral immune cell populations, particularly T cells. The precise mechanisms underlying microglial interactions with T cells and their contributions to immunosuppression remain incompletely understood. : This review comprehensively examines the complex cellular dialogue between microglia and T cells in two prominent brain malignancies: primary glioblastoma and secondary brain metastases. : Through a comprehensive review of the current scientific literature, we explore the nuanced mechanisms through which microglial-T cell interactions modulate tumor growth and immune responses. : Our analysis seeks to unravel the cellular communication pathways that potentially underpin tumor progression, with the ultimate goal of illuminating novel therapeutic strategies for brain cancer intervention.
脑癌是一种严峻的肿瘤学挑战，其特点是具有侵袭性且对传统治疗干预具有抗性。肿瘤微环境已成为肿瘤进展和治疗效果的关键决定因素。在这个复杂的生态系统中，小胶质细胞和巨噬细胞发挥着重要作用，与外周免疫细胞群体，特别是T细胞形成复杂的网络。小胶质细胞与T细胞相互作用的精确机制及其对免疫抑制的作用仍未完全了解。 本综述全面研究了两种主要脑恶性肿瘤——原发性胶质母细胞瘤和继发性脑转移瘤中小胶质细胞与T细胞之间复杂的细胞对话。 通过对当前科学文献的全面综述，我们探索了小胶质细胞 - T细胞相互作用调节肿瘤生长和免疫反应的细微机制。 我们的分析旨在揭示可能支撑肿瘤进展的细胞通讯途径，最终目标是为脑癌干预阐明新的治疗策略。
