Morsica Giulia, Locatelli Massimo, Hernandez-Ibarburu Gema, Rusconi Francesca, Segovia-Hilara Alba, Di Napoli Davide, Moro Matteo, Mazzitelli Salvatore, Hasson Hamid, Esposti Federico, Mazzuconi Roberts, Castagna Antonella
Infectious Diseases Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Laboratory Medicine Service, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
Microorganisms. 2025 Jan 10;13(1):129. doi: 10.3390/microorganisms13010129.
Free-of-charge hepatitis C virus antibody (HCV Ab) screening in some key populations and in 1969-1989 birth cohorts have been funded in Italy as the first step in confirming diagnosis in individuals who may be unaware of their infection. The purpose of this study is to leverage existing in-hospital routine screening data to better understand the distribution of HCV. A retrospective study of hospitalized patients (PTs) tested for HCV Ab for 5 years (from January 2017 to December 2022) in San Raffaele hospital was conducted according to age categories: birth year group before 1947 (patients older than 76 years old), birth year group 1947-1968, birth year group 1969-1989, and two other groups with birth year groups 1990-2000 and 2001-2022 (with patients younger than 33 years old) using the TriNetX platform. Among the 42,805 in-hospital PTs tested, 1297 (3.03%) were HCV Ab positive. The prevalence of HCV Ab was greater in PTs over the age of 76 (5.3%), whereas it was lower in the youngest birth year cohort (2000-2022, 0.16%). Among 1297 HCV Ab positive PTs, only 198 (15.3%) were tested for the presence of HCV RNA. The birth cohort 1969-1989 had a modest seroprevalence (1.5%), yet they were the most affected age group, with 44.4% being HCV RNA positive. The in-hospital HCV screening including birth year cohort 1947-1989 could be a more valuable option compared to the screening for birth year group 1969-1989 in the general population.
在意大利，对一些重点人群以及1969年至1989年出生队列进行免费丙型肝炎病毒抗体（HCV Ab）筛查，作为确认可能未意识到自身感染的个体诊断的第一步。本研究的目的是利用现有的医院常规筛查数据，以更好地了解HCV的分布情况。对圣拉斐尔医院5年（2017年1月至2022年12月）期间接受HCV Ab检测的住院患者（PTs）进行了回顾性研究，根据年龄类别划分：1947年以前出生年份组（76岁以上患者）、1947 - 1968年出生年份组、1969 - 1989年出生年份组，以及另外两个出生年份组1990 - 2000年和2001 - 2022年（年龄小于33岁的患者），使用TriNetX平台。在42,805名接受检测的住院PTs中，1297名（3.03%）HCV Ab呈阳性。76岁以上的PTs中HCV Ab患病率更高（5.3%），而最年轻的出生队列（2000 - 2022年）患病率较低（0.16%）。在1297名HCV Ab阳性的PTs中，仅198名（15.3%）进行了HCV RNA检测。1969 - 1989年出生队列的血清学患病率适中（1.5%），但他们是受影响最严重的年龄组，44.4%的人HCV RNA呈阳性。与在普通人群中对1969 - 1989年出生年份组进行筛查相比，包括1947 - 1989年出生队列的医院内HCV筛查可能是一个更有价值的选择。
