Arbab O A, Wiggins J, Ayres J G, Stableforth D E
Br J Dis Chest. 1985 Apr;79(2):161-71.
Parenteral theophylline usage was studied in 53 patients with worsening airflow obstruction who had been prescribed slow release theophylline drugs and were admitted to a hospital lacking facilities for rapid serum theophylline concentration estimation. Individual clinicians varied in their practice with respect to parenteral aminophylline, but in general its use was favoured in patients with asthma rather than simple chronic airflow obstruction. There was no significant difference in admission serum theophylline concentrations between 31 patients who were subsequently given intravenous aminophylline and 22 who were not. There was also no significant difference in admission serum theophylline concentrations between ten patients given an aminophylline bolus and an infusion, seven patients given a bolus alone and 14 patients given an infusion alone. Individual patient's serum theophylline concentrations were variable during infusions and often suboptimal. The results indicate that the use of parenteral aminophylline in patients receiving slow release theophyllines is imprecise and possibly hazardous without facilities for prompt serum theophylline concentration estimations. This facility should be available in hospitals where parenteral aminophylline is used.
对53例气流阻塞加重的患者使用了胃肠外茶碱，这些患者已被处方缓释放茶碱药物，并入住一家缺乏快速测定血清茶碱浓度设施的医院。个体临床医生在胃肠外氨茶碱的使用上存在差异，但总体而言，哮喘患者比单纯慢性气流阻塞患者更倾向于使用氨茶碱。随后接受静脉注射氨茶碱的31例患者与未接受的22例患者在入院时血清茶碱浓度上无显著差异。接受氨茶碱推注和输注的10例患者、仅接受推注的7例患者和仅接受输注的14例患者在入院时血清茶碱浓度上也无显著差异。在输注过程中，个体患者的血清茶碱浓度各不相同，且往往未达最佳水平。结果表明，在没有快速测定血清茶碱浓度设施的情况下，对接受缓释放茶碱的患者使用胃肠外氨茶碱不准确且可能有危险。在使用胃肠外氨茶碱的医院应具备这种检测设施。
