Klasik-Ciszewska Sylwia, Londzin Piotr, Grzywnowicz Kacper, Borymska Weronika, Zych Maria, Kaczmarczyk-Żebrowska Ilona, Folwarczna Joanna
Department of Pharmacology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Department of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland.
Nutrients. 2025 Jan 16;17(2):316. doi: 10.3390/nu17020316.
It seems that some substances of plant origin may exert health-promoting activities in diabetes and its complications, including those concerning bones. Chrysin (5,7-dihydroxyflavone), present in honey, some plants, and food of plant origin, has been reported to exert, among others, antioxidative, anti-inflammatory and antidiabetic effects. The aim of this study was to investigate the effects of chrysin on the skeletal system of rats with experimental type 1 diabetes (T1D).
The experiments were carried out on mature male Wistar rats. T1D was induced by a single streptozotocin injection. Administration of chrysin (50 or 100 mg/kg p.o., once daily) began two weeks later and lasted four weeks. Serum bone turnover markers, bone mass, density and mineralization, mechanical properties and histomorphometric parameters of cancellous and compact bone were examined.
T1D profoundly affected bone metabolism, leading to worsening of bone strength in comparison with the healthy controls. After administration of chrysin, slight improvement of only some parameters was demonstrated in relation to the diabetic controls.
Results of the present study indicate that chrysin may exert some very limited favorable effects on the skeletal system in diabetic conditions.
某些植物来源的物质似乎可能对糖尿病及其并发症（包括与骨骼相关的并发症）发挥促进健康的作用。据报道，存在于蜂蜜、某些植物及植物源性食物中的白杨素（5,7 - 二羟基黄酮）具有抗氧化、抗炎和抗糖尿病等作用。本研究的目的是探讨白杨素对实验性1型糖尿病（T1D）大鼠骨骼系统的影响。
实验选用成年雄性Wistar大鼠。通过单次注射链脲佐菌素诱导T1D。两周后开始给予白杨素（50或100mg/kg口服，每日一次），持续四周。检测血清骨转换标志物、骨量、密度和矿化情况、松质骨和皮质骨的力学性能以及组织形态计量学参数。
与健康对照组相比，T1D严重影响骨代谢，导致骨强度下降。给予白杨素后，与糖尿病对照组相比，仅部分参数略有改善。
本研究结果表明，白杨素在糖尿病情况下可能对骨骼系统发挥一些非常有限的有益作用。
