Boffano Paolo, Neirotti Francesca, Brucoli Matteo, Ruslin Muhammad, Pechalova Petia, Pavlov Nikolai, Sapundzhiev Angel, Uchikov Petar, Carlos de Vicente Rodríguez Juan, Torres Nerea Rodríguez, Santamarta Tania Rodríguez, Meyer Christophe, Louvrier Aurelien, Michel-Guillaneux Alexandre, Bertin Eugenie, Starch-Jensen Thomas, Stamatoski Aleksandar, Mijatov Ivana, Bajkin Branislav V, Dovsak Tadej, Garvas Zan, Durković Ana, Milosavljević Marija, Konstantinovic Vitomir, Degerholm Sara, Snäll Johanna
University of Eastern Piedmont, Novara, Italy; Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
University of Eastern Piedmont, Novara, Italy.
J Craniomaxillofac Surg. 2025 May;53(5):439-445. doi: 10.1016/j.jcms.2025.01.012. Epub 2025 Jan 24.
The purpose of this European multicenter study was to describe and assess the characteristics, diagnosis, management, and recurrence of oral malignant melanoma at different European oral and maxillofacial surgery centers.
This study was based on a systematic computer-assisted database that allowed the recording of data for all primary oral mucosal melanomas treated in the involved surgical units across Europe between January 1, 2003 and December 31, 2022. The following data were recorded for each patient: gender, age, site, TNM staging, metastases, symptoms, imaging features, histopathological features, treatment, complications, recurrence, follow up, and survival.
A total of 29 patients (15 females, 14 males) with a primary oral mucosal malignant melanoma fulfilled the inclusion criteria. The mean age was 64.4 years. The most frequent primary site was the vestibular and crestal maxillary gum. Nineteen patients had been diagnosed with a T3 oral melanoma, nine patients with a T4a oral melanoma, and one patient with a T4b neoplasm. Three patients had distant metastases at diagnosis. Clinically, the most frequently observed clinical features were hyperpigmentation, nodular appearance, ulceration, and hemorrhage. Among the 27 surgical cases, radical/clear margins were obtained in 24 cases, non-radical/invaded margins were obtained in two cases, while in one case a non-specific result of margin positivity was found. The overall 2-year survival was 62%. The 2-year disease-free survival was 52%.
Oral mucosal melanoma is an aggressive and often asymptomatic malignancy. The overall long-term survival for patients with oral mucosal melanoma is poor, with a high rate of distant metastasis, independently from the performed treatment. Prevention and early diagnosis could be crucial to improving the disease-free survival of patients with oral mucosal melanomas.
这项欧洲多中心研究的目的是描述和评估欧洲不同口腔颌面外科中心口腔恶性黑色素瘤的特征、诊断、治疗及复发情况。
本研究基于一个系统的计算机辅助数据库，该数据库记录了2003年1月1日至2022年12月31日期间欧洲各参与手术单位治疗的所有原发性口腔黏膜黑色素瘤的数据。记录了每位患者的以下数据：性别、年龄、部位、TNM分期、转移情况、症状、影像学特征、组织病理学特征、治疗、并发症、复发、随访及生存情况。
共有29例原发性口腔黏膜恶性黑色素瘤患者符合纳入标准（15例女性，14例男性）。平均年龄为64.4岁。最常见的原发部位是上颌前庭和牙槽嵴牙龈。19例患者被诊断为T3期口腔黑色素瘤，9例为T4a期口腔黑色素瘤，1例为T4b期肿瘤。3例患者在诊断时已有远处转移。临床上，最常观察到的临床特征是色素沉着、结节状外观、溃疡和出血。在27例手术病例中，24例获得了根治性/切缘阴性，2例获得了非根治性/切缘阳性，1例切缘阳性结果不明确。总体2年生存率为62%。2年无病生存率为52%。
口腔黏膜黑色素瘤是一种侵袭性强且通常无症状的恶性肿瘤。口腔黏膜黑色素瘤患者的总体长期生存率较差，远处转移率高，与所实施的治疗无关。预防和早期诊断对于提高口腔黏膜黑色素瘤患者的无病生存率可能至关重要。
