Vo Giang Thi Thu, Nguyen Khang Khoa Hoang, Kim Beom Soo
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Biotechnol Appl Biochem. 2025 Jan 26. doi: 10.1002/bab.2713.
The PnuC gene plays a crucial role in the complex processes related to the absorption and synthesis of the nicotinamide mononucleotide (NMN) precursor. NMN, a nicotinamide adenine dinucleotide (NAD) precursor, is important for cellular energy metabolism, DNA repair, and antiaging. This study focuses on elucidating the precursor absorption mechanism and the specific function of the PnuC gene in encoding membrane transport proteins, as well as its impact on the regulation and dynamics of NMN within the cell. This understanding aims to provide insights into its potential effects on metabolic balance, illustrated through two NAD biosynthesis pathways based on renewable and readily available cytoplasmic resources, assessing the potential of PnuC gene expression in clarifying complex interactions within regulation mechanisms. Enhanced expression analysis of the PnuC gene has initiated discussions on its potential applications in treating aging-related diseases and dysfunctions, contributing to cellular health maintenance.
PnuC基因在与烟酰胺单核苷酸（NMN）前体的吸收和合成相关的复杂过程中起着关键作用。NMN是烟酰胺腺嘌呤二核苷酸（NAD）的前体，对细胞能量代谢、DNA修复和抗衰老很重要。本研究着重阐明前体吸收机制以及PnuC基因在编码膜转运蛋白方面的具体功能，及其对细胞内NMN的调节和动态变化的影响。这种认识旨在通过基于可再生且易于获取的细胞质资源的两条NAD生物合成途径，深入了解其对代谢平衡的潜在影响，评估PnuC基因表达在阐明调节机制内复杂相互作用方面的潜力。对PnuC基因的增强表达分析引发了关于其在治疗与衰老相关疾病和功能障碍方面潜在应用的讨论，有助于维持细胞健康。
