Jacobson Samantha, Stetco Jonathan-Raphaël, Brown Richard, Garfield Natasha
Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada J1N 3C6.
Department of Obstetrics and Gynecology, McGill University Health Center, Montréal, QC, Canada H4A 3J1.
JCEM Case Rep. 2025 Jan 24;3(2):luaf013. doi: 10.1210/jcemcr/luaf013. eCollection 2025 Feb.
Hyperthyroidism in twin pregnancies involving a hydatidiform mole and a coexisting live fetus is a rare condition requiring careful management. We present a 34-year-old pregnant woman at 12 weeks' gestation with severe nausea, vomiting, and mild vaginal bleeding. A transvaginal ultrasound revealed a dichorionic diamniotic twin pregnancy with 1 normal fetus and 1 hydatidiform mole, leading to hyperthyroidism from elevated β human chorionic gonadotropin levels. Conservative management without antithyroid medications, combined with regular monitoring, allowed the pregnancy to continue to term, resulting in the delivery of a healthy baby at 39 weeks. Postpartum management required treatment of retained products of conception. This case highlights the complexities in the management of complications for both mother and fetus.
双胎妊娠合并葡萄胎及存活胎儿的甲状腺功能亢进是一种罕见情况,需要谨慎处理。我们报告一名34岁妊娠12周的孕妇,有严重恶心、呕吐和轻度阴道出血。经阴道超声显示为双绒毛膜双羊膜囊双胎妊娠,其中1个为正常胎儿,1个为葡萄胎,因β-人绒毛膜促性腺激素水平升高导致甲状腺功能亢进。在未使用抗甲状腺药物的情况下进行保守治疗,并定期监测,使妊娠得以持续至足月,孕妇在39周时分娩出一名健康婴儿。产后处理需要治疗残留的妊娠产物。该病例凸显了母亲和胎儿并发症处理的复杂性。