Sun Quan, Wei Yulong, Xie Hongting, Lyu Jiaxuan, Zhou Jingpei, Li Xinyu, Peng Wanqing, Zhao Renhui, Li Ziyuan, Chen Zhenhu, Lyu Jun, Wang Nanbu
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, PR China.
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, PR China.
Arch Gerontol Geriatr. 2025 Apr;131:105758. doi: 10.1016/j.archger.2025.105758. Epub 2025 Jan 13.
Late-life depression (LLD) represents a growing global public health concern. This study aimed to assess the worldwide burden of LLD using comprehensive data.
Leveraging the latest evidence from the Global Burden of Disease Study, we analyzed trends in LLD burden from 1990 to 2021, encompassing incidence, prevalence, and disability-adjusted life years (DALYs). We quantified disparities in LLD burden across socioeconomic, gender, regional, and national dimensions. Decomposition analysis was employed to identify key drivers of LLD burden variation. Frontier analysis illustrated the potential for burden reduction in various countries.
Globally, there were 49,137,544 new cases, 46,672,175 prevalent cases, and 7,351,377 DALYs attributed to LLD in 2021. Between 1990 and 2021, the agestandardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), and age-standardised DALYs rate (ASDR) of LLD all rose. In 2021, low SDI regions exhibited the highest all ASRs, while middle SDI regions had the fastest growth rates in these indicators. Regionally, Central and Eastern Sub-Saharan Africa had the highest ASIR, ASPR, and ASDR, respectively. Nationally, Uganda ranked highest in all ASRs in 2021. Women had higher burdens than men. Population growth was a primary driver of DALYs increase in middle SDI regions that had the greatest potential for improvement.
The global burden of LLD has risen, with marked inequities across SDI, gender, region, and country. The burden is most pronounced in low and middle SDI regions. These findings offer guidance for developing LLD screening guidelines and enhancing prevention and intervention strategies in relevant countries, particularly Uganda.
老年期抑郁症（LLD）是一个日益受到全球公共卫生关注的问题。本研究旨在利用综合数据评估全球范围内LLD的负担。
利用全球疾病负担研究的最新证据，我们分析了1990年至2021年LLD负担的趋势，包括发病率、患病率和伤残调整生命年（DALYs）。我们对社会经济、性别、区域和国家层面的LLD负担差异进行了量化。采用分解分析来确定LLD负担变化的关键驱动因素。前沿分析展示了各国减轻负担的潜力。
2021年，全球范围内归因于LLD的新发病例有49,137,544例，现患病例有46,672,175例，DALYs有7,351,377个。1990年至2021年期间，LLD的年龄标准化发病率（ASIR）、年龄标准化患病率（ASPR）和年龄标准化DALYs率（ASDR）均有所上升。2021年，社会人口指数（SDI）较低的地区所有年龄标准化率最高，而SDI中等的地区这些指标的增长率最快。在区域层面，撒哈拉以南非洲中部和东部地区的ASIR、ASPR和ASDR分别最高。在国家层面，乌干达在2021年所有年龄标准化率中排名最高。女性的负担高于男性。人口增长是SDI中等且改善潜力最大的地区DALYs增加的主要驱动因素。
LLD的全球负担有所上升，在SDI、性别、区域和国家之间存在明显的不平等。负担在SDI低和中等的地区最为明显。这些发现为制定LLD筛查指南以及加强相关国家（特别是乌干达）的预防和干预策略提供了指导。
