Blasutto Barbara, Fattapposta Francesco, Casagrande Maria
Department of Psychology, University of Rome "Sapienza", Rome 00185, Italy.
Department of Human Neuroscience, "Sapienza" University of Rome, Viale dell'Università 30, Rome 00185, Italy.
Ageing Res Rev. 2025 Mar;105:102668. doi: 10.1016/j.arr.2025.102668. Epub 2025 Jan 26.
Mild behavioral impairment (MBI) represents a recently introduced diagnostic concept that focuses on behavioral and personality changes occurring in late life and associated with cognitive decline. Nevertheless, the relationship between these dimensions remains unclear. This systematic review and meta-analysis aim to analyze the relationship between MBI and cognitive functioning. The review process was conducted according to the PRISMA-Statement. Restrictions were made, selecting the studies published in peer-review journals, including at least one cognitive measure and presenting the measurement of MBI. Studies that included participants with neurological disorders, dementia, or psychiatric disorders or that only did a neuroimaging or genetic study were excluded. Twenty-two studies were included in the systematic review, while in the meta-analysis seventeen studies featured data to be included in the analyses. The results were classified according to the following cognitive domains: global cognitive functioning, memory, language, attention executive functions, visuospatial skills, and processing speed. In the quantitative analysis, only global cognitive functioning, executive function, attention, and memory were evaluated. The results of both qualitative and quantitative analysis indicate that individuals with MBI exhibited diminished performance on cognitive tasks when compared to those without MBI symptoms. These results are stronger when evaluating the various domains individually (particularly memory and executive functions) than when a global assessment was made. These findings highlight the potential role of MBI symptoms as early indicators of neurodegenerative processes, reinforcing the necessity for comprehensive assessments that encompass both behavioral and cognitive evaluations. The early detection of these symptoms in prodromal phases can be very useful for the development of non-pharmacological interventions and may provide relevant guidelines for clinicians in the management and diagnosis of neurodegenerative disorders.
轻度行为损害（MBI）是一个最近引入的诊断概念，它关注于晚年出现的、与认知衰退相关的行为和人格变化。然而，这些维度之间的关系仍不明确。本系统评价和荟萃分析旨在分析MBI与认知功能之间的关系。评价过程按照PRISMA声明进行。设定了限制条件，选择发表在同行评审期刊上的研究，这些研究至少包含一项认知测量并呈现MBI的测量方法。排除了纳入患有神经疾病、痴呆或精神疾病参与者的研究，或仅进行神经影像学或基因研究的研究。系统评价纳入了22项研究，而荟萃分析中有17项研究的数据纳入分析。结果根据以下认知领域进行分类：整体认知功能、记忆、语言、注意力执行功能、视觉空间技能和处理速度。在定量分析中，仅评估了整体认知功能、执行功能、注意力和记忆。定性和定量分析的结果均表明，与没有MBI症状的个体相比，患有MBI的个体在认知任务上表现较差。单独评估各个领域（特别是记忆和执行功能）时的结果比进行整体评估时更强。这些发现凸显了MBI症状作为神经退行性过程早期指标的潜在作用，强化了进行涵盖行为和认知评估的全面评估的必要性。在前驱期早期发现这些症状对于非药物干预措施的制定可能非常有用，并可能为临床医生在神经退行性疾病的管理和诊断中提供相关指导。
