溶质载体家族26成员9（SLC26A9）通过激活PI3K/AKT信号通路促进乳腺癌的发生和发展。
SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway.
作者信息
Ma Zhiyuan, Wang Hu, Zhou Zhengxing, Lu Chengli, Zhang Minglin, Mu Renmin, Zhang Chengmin, Yi Zhiqiang, Deng Zilin, Zhao Yingying, Zhu Jiaxing, Wen Guorong, Jin Hai, An Jiaxing, Tuo Biguang, Yuan Peng, Liu Xuemei, Li Taolang
机构信息
Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Department of Gastroenterology, Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Department of General Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China; Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
出版信息
Biochim Biophys Acta Mol Cell Res. 2025 Mar;1872(3):119912. doi: 10.1016/j.bbamcr.2025.119912. Epub 2025 Jan 27.
SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.
SLC26A9是多功能阴离子转运体Slc26a家族的成员，在胃中作为氯离子通道发挥作用。我们首次报道SLC26A9参与胃癌发生。然而，SLC26A9在乳腺癌中的作用尚未得到研究。我们首先证明，SLC26A9的上调与乳腺癌患者的临床病理进展和不良预后相关，且与HER2扩增呈正相关。SLC26A9通过调节PI3K/AKT信号通路改变乳腺癌细胞的增殖、迁移和侵袭潜能。SLC26A9在乳腺癌发展中起癌基因作用。这些发现为未来乳腺癌诊断和治疗策略的开发提供了有价值的见解。
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