Krammer Werner, Missimer John H, Vallesi Vanessa, Pastore-Wapp Manuela, Kägi Georg, Wiest Roland, Weder Bruno J
Support Centre for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Sci Rep. 2025 Jan 29;15(1):3641. doi: 10.1038/s41598-025-86157-x.
This study aims to establish an imitation task of multi-finger haptics in the context of regular grasping and regrasping processes during activities of daily living. A video guided the 26 healthy, right-handed volunteers through the three phases of the task: (1) fixation of a hand holding a cuboid, (2) observation of the sensori-motor manipulation, (3) imitation of that motor action. fMRI recorded the task; graph analysis of the acquisitions revealed the associated functional cerebral connectivity patterns. Inferred from four 60 ROI weighted graphs, the functional connectivities are consistent with a motor plan for observation and manipulation in the left hemisphere and with a network in the right hemisphere involving the inferior frontal gyrus, the site of intentional control of imitation. The networks exhibit (1) rich clubs which include sensori-motor hand, dorsal attention and cingulo-opercular communities for observation and motor execution in both hemispheres and (2) diversity clubs, significant only for manipulation and observation of the left hand, which include the dorsal visual association cortex, suggesting enhanced visual perception required for guiding the movement-limited left fingers. Short pathway analyses are consistent with these findings, confirming preferential involvement of ventral premotor cortices in the mirror network.
本研究旨在建立一种在日常生活活动中常规抓握和重新抓握过程背景下的多指触觉模仿任务。一段视频引导26名健康的右利手志愿者完成任务的三个阶段：(1) 握住长方体的手部固定，(2) 感觉运动操作观察，(3) 该运动动作的模仿。功能磁共振成像记录了该任务；对采集数据的图形分析揭示了相关的功能性脑连接模式。从四个60个感兴趣区域加权图推断，功能连接与左半球观察和操作的运动计划一致，与右半球涉及额下回（模仿的有意控制部位）的网络一致。这些网络表现出：(1) 富俱乐部，包括感觉运动手部、背侧注意和扣带回-岛叶网络，用于双侧半球的观察和运动执行；(2) 多样性俱乐部，仅在左手操作和观察时显著，包括背侧视觉联合皮层，表明引导运动受限的左手手指需要增强视觉感知。短通路分析与这些发现一致，证实了腹侧运动前皮层在镜像网络中的优先参与。
