The Clinical Impression of NDM-producing in Intensive Care Units of the University Referral Hospital in North India.

AIMS AND BACKGROUND

Carbapenem-resistant (CRAb), a major public health threat, causes severe infections in Intensive Care Unit (ICU) patients. It resists β-lactam antibiotics through mechanisms like New Delhi metallo-beta-lactamase (NDM).

MATERIALS AND METHODS

In ICU patients, 69 species were isolated from 86 non-fermenting Gram-negative bacilli. Isolates were identified using biochemical methods and Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS), and carbapenem resistance detection was done by both phenotypic (mCIM and eCIM) and molecular methods.

RESULTS

Out of 66 , 61 were carbapenem-resistant, with 20 confirmed as NDM producers. NDM-positive isolates exhibited higher resistance and were associated with significant mortality (75%).

CONCLUSION

NDM-positive isolates are significant ICU pathogens with poor outcomes. Key risk factors include prolonged ICU stays, prior antimicrobial use, and inadequate therapy. Early detection and infection control are crucial.

CLINICAL SIGNIFICANCE

NDM-positive infections in ICU patients are linked to poor outcomes, highlighting the need for early detection and control measures.

HOW TO CITE THIS ARTICLE

Singh S, Verma A, Venkatesh V, Verma S, Reddy DH, Agrawal A. The Clinical Impression of NDM-producing in Intensive Care Units of the University Referral Hospital in North India. Indian J Crit Care Med 2024;28(11):1044-1049.