Fordham Sarah, Ashurst Karen, Bartoletti Alice, Coath Fiona L, Ducker Georgina, Kamath Ajay, Mushtaq Warda, Naeem Hassan, Nicholls Isabelle, Sheehy Claire, Sisson Katherine, Watts Richard, Mukhtyar Chetan B
Department of Rheumatology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Department of Immunology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.
Rheumatology (Oxford). 2025 Jun 1;64(6):3718-3723. doi: 10.1093/rheumatology/keaf052.
The aim of this study was to report the annual and age-specific incidence of AAV and PAN in the adult population of Norfolk County, UK.
Individuals newly diagnosed with AAV or PAN between 1 January 2011 and 31 December 2020 residing in the postal areas of NR1-NR30 were included. Patients were classified according to the European Medicines Agency algorithm. Population data were available from the Office of National Statistics, UK.
A total of 164 patients were diagnosed with AAV or PAN over 4.7 million person-years. The annual incidence (95% CI) of AAV was 34.3 (29.2, 40)/million person-years. The annual incidence (95% CI) of granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis was 18.9 (15.2, 23.3), 12.8 (9.7, 16.4) and 2.6 (1.3, 4.5)/million person-years, respectively. The annual incidence (95% CI) for PAN was 0.6 (0.1, 1.9)/million person-years. The age-specific incidence of granulomatosis with polyangiitis and microscopic polyangiitis rose with each decade of life and was highest in the 8th decade for granulomatosis with polyangiitis [53.2 (95% CI 36.2, 75.6) per million] and in the 9th decade for microscopic polyangiitis [48.4 (95% CI 27.1, 79.8) per million].
The incidence of AAV, specifically that of granulomatosis with polyangiitis and of microscopic polyangiitis, is slowly rising over time. It is most notable among the elderly population, among whom the incidence rates for granulomatosis with polyangiitis and microscopic polyangiitis peak. There may be a 4-year incidence cycle, which needs confirmation in a longer study.
本研究旨在报告英国诺福克郡成年人群中抗中性粒细胞胞浆抗体相关性血管炎（AAV）和结节性多动脉炎（PAN）的年度发病率及特定年龄发病率。
纳入2011年1月1日至2020年12月31日期间居住在NR1 - NR30邮政区域内新诊断为AAV或PAN的个体。患者根据欧洲药品管理局的算法进行分类。人口数据来自英国国家统计局。
在超过470万人年的时间里，共有164例患者被诊断为AAV或PAN。AAV的年度发病率（95%置信区间）为每百万人口年34.3（29.2，40）例。肉芽肿性多血管炎、显微镜下多血管炎和嗜酸性肉芽肿性多血管炎的年度发病率（95%置信区间）分别为每百万人口年18.9（15.2，23.3）例、12.8（9.7，16.4）例和2.6（1.3，4.5）例。PAN的年度发病率（95%置信区间）为每百万人口年0.6（0.1，1.9）例。肉芽肿性多血管炎和显微镜下多血管炎的特定年龄发病率随年龄每增长十岁而上升，肉芽肿性多血管炎在第8个十年发病率最高[每百万人口年53.2（95%置信区间36.2，75.6）例]，显微镜下多血管炎在第9个十年发病率最高[每百万人口年48.4（95%置信区间27.1，79.8）例]。
AAV的发病率，特别是肉芽肿性多血管炎和显微镜下多血管炎的发病率，随时间缓慢上升。在老年人群中最为显著，其中肉芽肿性多血管炎和显微镜下多血管炎的发病率达到峰值。可能存在一个4年的发病周期，这需要在更长时间的研究中得到证实。
