下一代测序在神经系统感染中的诊断效用：两个实例
Diagnostic utility of next-generation sequencing in neurological infections: Two cases in point.
作者信息
Kandikuppa Ravi Teja, Krishna Vidya, Sethuraman Nandini, Sridhar Anuradha, Paramasivam Srinivasan
机构信息
Department of Infectious Diseases, Apollo Hospitals, Chennai, 600006, India.
Department of Infectious Diseases, Apollo Hospitals, Chennai, 600006, India.
出版信息
Diagn Microbiol Infect Dis. 2025 Mar;111(3):116713. doi: 10.1016/j.diagmicrobio.2025.116713. Epub 2025 Jan 23.
We report the successful management of two cases of brain abscess and subdural empyema caused by Fusobacterium nucleatum and Streptococcus intermedius diagnosed using 16S ribosomal RNA (rRNA) sequencing where microbiological culture showed no growth. This report elucidates the utility of next-generation sequencing (NGS) in determining the microbial etiology and guiding appropriate antimicrobial treatment in life-threatening neurological infections.
我们报告了两例由具核梭杆菌和中间链球菌引起的脑脓肿和硬膜下积脓的成功治疗案例，这两例是通过16S核糖体RNA（rRNA）测序诊断出来的，而微生物培养显示无生长。本报告阐明了下一代测序（NGS）在确定危及生命的神经系统感染的微生物病因和指导适当抗菌治疗方面的效用。
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