Wang Qianqian, Wang Congyao, Su Yihua, Yu Fenfen, Chen Tingting, Dong Xia, Wan Pengxia
Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhongshan Er Road, Guangzhou, 510080, Guangdong, People's Republic of China.
Eye Vis (Lond). 2025 Feb 1;12(1):4. doi: 10.1186/s40662-024-00419-9.
To identify foveal structure-function topographic association and relationship in patients with idiopathic epiretinal membrane (ERM) related to ectopic inner foveal layer (EIFL).
This was a cross-sectional, observational study that involved 40 individuals with idiopathic ERM: 22 without EIFL (Group 1) and 18 with EIFL (Group 2). Quantitative foveal light sensitivity was measured using microperimetry, and foveal microstructure was assessed using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA). Multiple indices of microvascular parameters of OCTA images were further processed using the AngioTool software. LASSO regression and quantile regression analyses were performed to identify the spatial distribution correlation between foveal light sensitivity and foveal microstructure parameters.
Group 2 exhibited reduced light sensitivity across all parameters of microperimetry compared to Group 1 (P < 0.001). Additionally, the central foveal thickness, the percentage of ellipsoid zone disruption, and the foveal avascular zone area were significantly lower in Group 1 than in Group 2 (all P < 0.005). Compared to Group 1, the vessel density (VD) and perfusion density of the foveal region was significantly increased in Group 2 (P < 0.001). In contrast, Group 2 showed significantly decreased VD in the parafoveal region compared with Group 1 (P < 0.05). Significant differences in OCTA parameters including 'total number of junctions', 'junction density', 'total vessel length', 'average vessel length', 'total number of end points' were observed between Group 1 and Group 2 (all P < 0.01). The foveal light sensitivity was significantly positively correlated with VD in the parafoveal region and negatively correlated with EIFL alteration, best-corrected visual acuity and ellipsoid zone disruption [Log(λ) = - 0.18303, λ = 0.6561].
The presence of EIFL and decreased VD in the parafoveal region, factors that collectively elevate the risk of disease progression, are significantly and independently correlated with reduced microperimetric retinal sensitivity in patients with idiopathic ERM.
确定与黄斑中心凹内层异位（EIFL）相关的特发性视网膜前膜（ERM）患者黄斑中心凹结构 - 功能的地形学关联及关系。
这是一项横断面观察性研究，纳入了40例特发性ERM患者：22例无EIFL（第1组），18例有EIFL（第2组）。使用微视野计测量黄斑中心凹的定量光敏感度，并使用光谱域光学相干断层扫描（SD - OCT）和光学相干断层扫描血管造影（OCTA）评估黄斑中心凹的微观结构。使用AngioTool软件进一步处理OCTA图像的微血管参数的多个指标。进行LASSO回归和分位数回归分析，以确定黄斑中心凹光敏感度与黄斑中心凹微观结构参数之间的空间分布相关性。
与第1组相比，第2组在微视野计的所有参数上均表现出光敏感度降低（P < 0.001）。此外，第1组的黄斑中心凹厚度、椭圆体带破坏百分比和黄斑无血管区面积均显著低于第2组（所有P < 0.005）。与第1组相比，第2组黄斑中心凹区域的血管密度（VD）和灌注密度显著增加（P < 0.001）。相比之下，与第1组相比，第2组在黄斑旁区域的VD显著降低（P < 0.05）。在第1组和第2组之间观察到OCTA参数的显著差异，包括“连接总数”、“连接密度”、“总血管长度”、“平均血管长度”、“端点总数”（所有P < 0.01）。黄斑中心凹光敏感度与黄斑旁区域的VD显著正相关，与EIFL改变、最佳矫正视力和椭圆体带破坏呈负相关[Log(λ) = - 0.18303，λ = 0.6561]。
EIFL的存在以及黄斑旁区域VD降低，这些因素共同增加了疾病进展的风险，与特发性ERM患者微视野计测量的视网膜敏感度降低显著且独立相关。
