Alonso-Bivou Mariano, Pol Albert, Lo Harriet P
Lipid Trafficking and Disease Group, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.
Lipid Trafficking and Disease Group, Institut D'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain; Department of Biomedical Sciences, Faculty of Medicine, Universitat de Barcelona, 08036, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain.
Curr Opin Cell Biol. 2025 Apr;93:102466. doi: 10.1016/j.ceb.2025.102466. Epub 2025 Feb 1.
Lipid droplets (LDs) play crucial roles in lipid metabolism, energy homeostasis, and cellular stress. Throughout their lifecycle, LDs establish membrane contact sites (MCSs) with the endoplasmic reticulum, mitochondria, peroxisomes, endosomes, lysosomes, and phagosomes. LD MCSs are dynamically generated in response to metabolic or immune cues to ensure that LD lipids (and proteins) are timely delivered to optimize valuable substrates and avoid lipotoxicity. It is increasingly evident that many Rab GTPases are involved in LD dynamics. Here, we summarize our current understanding of how and when Rab proteins dynamically drive the generation of LD MCSs and regulate a variety of LD functions.
脂滴（LDs）在脂质代谢、能量稳态和细胞应激中发挥着关键作用。在其整个生命周期中，脂滴与内质网、线粒体、过氧化物酶体、内体、溶酶体和吞噬体建立膜接触位点（MCSs）。脂滴膜接触位点会根据代谢或免疫信号动态生成，以确保脂滴脂质（和蛋白质）能及时输送，从而优化有价值的底物并避免脂毒性。越来越明显的是，许多Rab GTP酶参与了脂滴动态变化。在此，我们总结了目前对Rab蛋白如何以及何时动态驱动脂滴膜接触位点的产生并调节多种脂滴功能的理解。
