Cheng Yuan, Li Xiangcheng
Department of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China.
Hepatobiliary Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Heliyon. 2024 Dec 25;11(2):e41356. doi: 10.1016/j.heliyon.2024.e41356. eCollection 2025 Jan 30.
The high recurrence rate and dismal prognosis of localized intrahepatic cholangiocarcinoma (ICC) indicate the unmet need for effective adjuvant and neoadjuvant therapy. In recent years, progress has been made in immunotherapy and targeted therapy for the treatment of advanced biliary tract cancer (BTC), leading to clinical exploration of the provision of these therapies in the perioperative period. Based on years of experience in clinical research on hepatobiliary cancers, the authors discuss the design of studies on neoadjuvant therapy for ICC, aiming to provide references for future neoadjuvant studies.
局限性肝内胆管癌(ICC)的高复发率和预后不佳表明,对于有效的辅助治疗和新辅助治疗仍存在未满足的需求。近年来,晚期胆管癌(BTC)的免疫治疗和靶向治疗取得了进展,促使人们对在围手术期提供这些治疗进行临床探索。基于多年肝胆癌临床研究经验,作者探讨了ICC新辅助治疗的研究设计,旨在为未来的新辅助研究提供参考。