Ikeda Y, Higashijima T, Oguchi Y, Okumura K, Ozeki M, Okada A
Jpn J Antibiot. 1985 Jan;38(1):145-54.
Cefsulodin (CFS), a cephem antibiotic, was administered to 26 children aged from 11 months to 11 years by intravenous injection or intravenous 1-hour drip infusion in doses of 15 and 50 mg/kg body weight to investigate serum and urinary concentrations. The following results were obtained. Serum concentration The serum concentrations of CFS at 5 minutes after intravenous injection of 15 and 50 mg/kg were 57.1 and 224.2 micrograms/ml, respectively. The biological half-lives (T 1/2 beta) were 1.28 and 1.12 hours. The serum concentration of CFS after intravenous 1-hour drip infusion reached a peak at the end of infusion, i.e. 29.9 micrograms/ml for 15 mg/kg and 121.9 micrograms/ml for 50 mg/kg, and T 1/2 beta were 1.22 hours for 15 mg/kg and 1.27 hours for 50 mg/kg. The AUC was proportional to the doses for both intravenous injection and intravenous drip infusion. The serum clearance was about twice the value in adults and the distribution volume was about 1.5 times as large. Urinary excretion The urinary excretion up to 6 hours after administration was: 69.0% for 15 mg/kg and 61.9% for 50 mg/kg in cases of intravenous injection, and 62.4% for 15 mg/kg and 71.1% for 50 mg/kg in cases of intravenous 1-hour drip infusion. The percent urinary excretion was similar to that in adults.
头孢磺啶（CFS），一种头孢菌素类抗生素，对26名年龄在11个月至11岁的儿童进行静脉注射或静脉1小时滴注，剂量为15和50mg/kg体重，以研究血清和尿液浓度。得到以下结果。血清浓度：静脉注射15和50mg/kg后5分钟时CFS的血清浓度分别为57.1和224.2μg/ml。生物半衰期（T1/2β）分别为1.28和1.12小时。静脉1小时滴注后CFS的血清浓度在滴注结束时达到峰值，即15mg/kg时为29.9μg/ml，50mg/kg时为121.9μg/ml，15mg/kg时T1/2β为1.22小时，50mg/kg时为1.27小时。静脉注射和静脉滴注的AUC均与剂量成正比。血清清除率约为成人的两倍，分布容积约为成人的1.5倍。尿液排泄：给药后6小时内的尿液排泄情况为：静脉注射时，15mg/kg为69.0%，50mg/kg为61.9%；静脉1小时滴注时，15mg/kg为62.4%，50mg/kg为71.1%。尿液排泄百分比与成人相似。
