Rogoznica Marija, Radić Mislav, Belančić Andrej, Skroče Kristina, Vurić Karla, Kehler Tatjana
Hospital for Medical Rehabilitation of Heart and Lung Diseases and Rheumatism 'Thalassotherapia-Opatija', Opatija, 51410, Croatia.
Department of Rheumatology and Clinical Immunology, University Hospital Split, Split, 21000, Croatia.
Rheumatol Int. 2025 Feb 4;45(2):42. doi: 10.1007/s00296-025-05788-5.
Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease which causes a major deterioration of both physical and mental health. This research aimed to assess the prevalence of sexual dysfunction (SD), decreased quality of life (QoL), and depressive and anxiety symptoms in women with non-radiographic axial spondyloarthritis (nr-axSpA). A cross-sectional study was performed, involving 60 sexually active women with nr-axSpA and an age-matched group of 60 healthy women. Data were gathered through patient records and three standardized tools: the Female Sexual Function Index (FSFI), the Hospital Anxiety and Depression Scale (HADS), and the Short Form-36 (SF-36). Sexual dysfunction was found to be more prevalent in the nr-axSpA group (65% vs. 40%, p < 0.01). The mean FSFI result was substantially lower in patients than in healthy controls (19.71 ± 11.32 vs. 24.75 ± 8.36, p < 0.01) with significant differences of the scores in desire, arousal, lubrication and pain caused during intercourse. Women with nr-axSpA also experienced higher levels of anxiety (HADS-A: 8.52 ± 3.62 vs. 5.88 ± 3.83, p < 0.01) and depression (HADS-D: 6.27 ± 3.38 vs. 3.28 ± 2.77, p < 0.01). They also had lower physical (171.0 ± 72.9 vs. 301.5 ± 81.2, p < 0.01) and mental (204.9 ± 83.9 vs. 277.1 ± 74.5, p < 0.01) QoL scores. Women diagnosed with nr-axSpA are more prone to sexual dysfunction, increased anxiety and depression, and have a significantly worsened quality of life. The obtained results accentuate the necessity of addressing the patients' physical as well as their emotional issues through a comprehensive approach.
轴性脊柱关节炎（ax-SpA）是一种慢性炎症性疾病，会导致身心健康严重恶化。本研究旨在评估非放射学轴性脊柱关节炎（nr-axSpA）女性患者性功能障碍（SD）、生活质量（QoL）下降以及抑郁和焦虑症状的患病率。进行了一项横断面研究，纳入60名有性活动的nr-axSpA女性患者以及60名年龄匹配的健康女性。通过患者记录和三种标准化工具收集数据：女性性功能指数（FSFI）、医院焦虑抑郁量表（HADS）和简明健康调查量表（SF-36）。发现nr-axSpA组性功能障碍更为普遍（65%对40%，p<0.01）。患者的FSFI平均结果显著低于健康对照组（19.71±11.32对24.75±8.36，p<0.01），在性欲、性唤起、阴道润滑和性交疼痛方面的得分存在显著差异。nr-axSpA女性患者的焦虑水平（HADS-A：8.52±3.62对5.88±3.83，p<0.01）和抑郁水平（HADS-D：6.27±3.38对3.28±2.77，p<0.01）也更高。她们的生理（171.0±72.9对301.5±81.2，p<0.01）和心理（204.9±83.9对277.1±74.5，p<0.01）生活质量得分也更低。被诊断为nr-axSpA的女性更容易出现性功能障碍、焦虑和抑郁增加，生活质量明显恶化。所得结果强调了通过综合方法解决患者身体和情感问题的必要性。
