Guo Shiyuan, Lin Yilong, Li Junting, Zheng Yan, Lan Xin, Chen Jiaojiao, Li Shuying, Feng Yingjie, Wang Songsong
College of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
School of Medicine, Xiamen University, Xiamen, China.
J Asthma. 2025 Jul;62(7):1156-1165. doi: 10.1080/02770903.2025.2463973. Epub 2025 Feb 13.
Both depression and asthma have a significant impact on the quality of life for individuals. Studies have shown that patients with depression often experience comorbid asthma; however, the precise relationship between these two conditions remains unclear. The objective of this study is to investigate the causal relationship between depression and asthma.
In a cross-sectional study, we utilized data from the National Health and Nutrition Examination Survey (NHANES) 2009-2014 and employed logistic regression to assess the correlation between depression and asthma. In the subsequent Mendelian randomization (MR) analysis, we selected single nucleotide polymorphisms (SNPs) closely linked to both depression and asthma as instrumental variables, based on summary data from genome-wide association studies (GWAS). The inverse variance weighted method (IVW) was then applied to ascertain the causal relationship between depression and asthma.
Based on the results of the cross-sectional study, it was found that the status of depression was significantly associated with a higher risk of asthma (OR = 2.15, 95%CI = 1.79 ∼ 2.59, < 0.001). Furthermore, in the MR analysis, a causal relationship was further identified between depression, severe depression, and the increased incidence of asthma (OR = 1.11, 95%CI = 1.05 ∼ 1.18, < 0.001), (OR = 1.01, 95%CI = 1.01 ∼ 1.02, < 0.001); the results of the reverse MR analysis indicated no causal relationship between asthma and the increased incidence of depression and severe depression (OR = 1.01, 95%CI0.99 ∼ 1.03, = 0.50), (OR = 1.07, 95%CI: 0.82 ∼ 1.40, = 0.64).
This study has revealed a causal relationship between depression and an increased risk of developing asthma, offering new insights for the clinical intervention of both asthma and depression.
抑郁症和哮喘均对个体生活质量有重大影响。研究表明，抑郁症患者常合并哮喘；然而，这两种疾病的确切关系仍不明确。本研究的目的是调查抑郁症与哮喘之间的因果关系。
在一项横断面研究中，我们利用了2009 - 2014年美国国家健康与营养检查调查（NHANES）的数据，并采用逻辑回归评估抑郁症与哮喘之间的相关性。在随后的孟德尔随机化（MR）分析中，我们基于全基因组关联研究（GWAS）的汇总数据，选择与抑郁症和哮喘均紧密相关的单核苷酸多态性（SNP）作为工具变量。然后应用逆方差加权法（IVW）来确定抑郁症与哮喘之间的因果关系。
基于横断面研究结果，发现抑郁状态与哮喘风险升高显著相关（OR = 2.15，95%CI = 1.79 ∼ 2.59，P < 0.001）。此外，在MR分析中，进一步确定了抑郁症、重度抑郁症与哮喘发病率增加之间存在因果关系（OR = 1.11，95%CI = 1.05 ∼ 1.18，P < 0.001），（OR = 1.01，95%CI = 1.01 ∼ 1.02，P < 0.001）；反向MR分析结果表明，哮喘与抑郁症及重度抑郁症发病率增加之间不存在因果关系（OR = 1.01，95%CI 0.99 ∼ 1.03，P = 0.50），（OR = 1.07，95%CI：0.82 ∼ 1.40，P = 0.64）。
本研究揭示了抑郁症与哮喘发病风险增加之间的因果关系，为哮喘和抑郁症的临床干预提供了新的见解。
