间歇性禁食：对肥胖相关结直肠癌发生的影响。
Intermittent Fasting: Implications for Obesity-Related Colorectal Tumorigenesis.
作者信息
Peñalver Bernabé Beatriz, Oliveira Manoela Lima, Wolf Patricia G, McLeod Andrew, Gabel Kelsey, Cares Kate, Robinson Nadia, DiPiazza Brittany, Varady Krista, Tussing-Humphreys Lisa
机构信息
Department of Biomedical Engineering, University of Illinois Chicago, 851 South Morgan Street, Chicago, IL, USA; Center for Bioinformatics and Quantitative Biology, University of Illinois Chicago, Chicago, IL, USA.
Department of Kinesiology and Nutrition, University of Illinois Chicago, 1919 West Taylor Street, Chicago, IL, USA; University of Illinois Cancer Center, Chicago, IL, USA.
出版信息
Endocrinol Metab Clin North Am. 2025 Mar;54(1):61-83. doi: 10.1016/j.ecl.2024.10.007.
Obesity is associated with metabolic and immune perturbations (ie, insulin resistance, increased inflammation, and oxidative stress), circadian rhythm dysregulation, and gut microbial changes that can promote colorectal tumorigenesis. Colorectal cancer (CRC) is the third most incident cancer in the United States. This narrative review examines the effects of intermittend fasting on factors influencing colon tumorigenesis, such as body weight, metabolic and immune markers, circadian rythm, and the gut microbiota in humans. Findings suggest that intermittent fasting regimens can lead to weight loss and shifts in metabolic markers, which could be preventive for CRC but effects on the gut microbiota composition and functions still remains elusive.
肥胖与代谢和免疫紊乱（即胰岛素抵抗、炎症增加和氧化应激）、昼夜节律失调以及可促进结直肠癌发生的肠道微生物变化有关。结直肠癌（CRC）是美国第三大常见癌症。这篇叙述性综述探讨了间歇性禁食对影响结肠肿瘤发生的因素的作用，如体重、代谢和免疫标志物、昼夜节律以及人体肠道微生物群。研究结果表明，间歇性禁食方案可导致体重减轻和代谢标志物的变化，这可能对结直肠癌具有预防作用，但对肠道微生物群组成和功能的影响仍不明确。
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