Malloy C R, Matthews P M, Smith M B, Radda G K
Adv Myocardiol. 1985;6:461-4.
We applied 31P nuclear magnetic resonance to the study of acute ischemia in vivo. In open-chest rabbits, the left anterior descending coronary artery was occluded after control spectra were obtained. Phosphocreatine concentration decreased in the first minute and ATP concentration declined subsequently, and pH decreased to 5.8 within 20 min. Intracellular acidosis was greater than that previously reported for the isolated perfused rabbit heart.
我们将31P核磁共振技术应用于体内急性缺血的研究。在开胸兔身上，在获得对照光谱后，闭塞左冠状动脉前降支。磷酸肌酸浓度在第一分钟下降，随后ATP浓度下降，pH值在20分钟内降至5.8。细胞内酸中毒程度比先前报道的离体灌注兔心脏更严重。
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