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玻利维亚恰加斯心肌病患者的当代管理

Contemporary Management of Patients With Chagas Cardiomyopathy in Bolivia.

作者信息

Czulada Evan, Bercovitch Sascha, Alshawkani Yazan, Noya Weise Natalia, Hernani Rodrigo Adriana E, Durán Saucedo Ronald Gustavo, Buhezo Chamón Marcelo, Gilman Robert H, Martin David T

机构信息

Georgetown University School of Medicine, Washington, DC, USA.

Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

出版信息

JACC Adv. 2025 Mar;4(3):101588. doi: 10.1016/j.jacadv.2025.101588. Epub 2025 Feb 7.

Abstract

BACKGROUND

Chagas cardiomyopathy (CCM) is the debilitating result of a parasitic infection that causes structural and electrical abnormalities. Yet, optimal CCM management is challenging in the resource-poor communities where it predominates.

OBJECTIVES

The authors sought to investigate current practice patterns and barriers to CCM care through an online survey of cardiologists in Bolivia, the country with the highest CCM prevalence.

METHODS

Cardiologists were recruited through the national cardiologist directory. The Qualtrics survey was distributed anonymously. Survey questions were developed by Bolivian and U.S. researchers with extensive Chagas disease experience.

RESULTS

Of 194 cardiologists, 67 (35%) completed ≥80% of the survey. Responses were collected from every major Bolivian city. More than 70% of cardiologists cared for CCM patients daily or weekly. More frequent prescription of angiotensin-converting enzyme inhibitors (73%) and mineralocorticoid receptor antagonists (82%) for heart failure was reported compared to β-blockers. Ventricular tachycardia treatment was achieved more often with amiodarone (92%) than implantable cardioverter-defibrillators (46%). Anticoagulation was prescribed if CCM patients had atrial fibrillation (91%) or apical aneurysm with thrombus (86%), yet few cardiologists prescribed anticoagulation in left ventricular systolic dysfunction or CCM diagnosis alone. While pacemaker therapy was generally available to cardiologists (66%), patients received devices only through private insurance or philanthropy, with few physicians (28%) offering implantable cardioverter-defibrillators regularly.

CONCLUSIONS

Cardiologists cited lack of device access as the predominant challenge in CCM management rather than insufficient knowledge or experience. These findings suggest that significant health equity gaps remain in CCM care, particularly in the availability of commonly indicated, potentially life-saving devices.

摘要

背景

恰加斯心肌病(CCM)是一种寄生虫感染导致的使人衰弱的疾病,会引起结构和电生理异常。然而,在CCM高发的资源匮乏社区,优化CCM管理具有挑战性。

目的

作者试图通过对玻利维亚CCM患病率最高的国家的心脏病专家进行在线调查,来研究CCM护理的当前实践模式和障碍。

方法

通过国家心脏病专家名录招募心脏病专家。Qualtrics调查以匿名方式分发。调查问题由具有丰富恰加斯病经验的玻利维亚和美国研究人员制定。

结果

在194名心脏病专家中,67名(35%)完成了≥80%的调查。回复来自玻利维亚的每个主要城市。超过70%的心脏病专家每天或每周护理CCM患者。与β受体阻滞剂相比,报告的用于心力衰竭的血管紧张素转换酶抑制剂(73%)和盐皮质激素受体拮抗剂(82%)的处方更频繁。胺碘酮(92%)比植入式心律转复除颤器(46%)更常用于治疗室性心动过速。如果CCM患者患有房颤(91%)或伴有血栓的心尖部动脉瘤(86%),则会开具抗凝药,但很少有心脏病专家在左心室收缩功能障碍或仅诊断为CCM时开具抗凝药。虽然心脏病专家通常可以获得起搏器治疗(66%),但患者仅通过私人保险或慈善机构获得设备,很少有医生(28%)定期提供植入式心律转复除颤器。

结论

心脏病专家认为设备获取困难是CCM管理中的主要挑战,而非知识或经验不足。这些发现表明,CCM护理中仍存在显著的健康公平差距,特别是在常用的、可能挽救生命的设备的可及性方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/137e/11850122/08c770134a5d/ga1.jpg

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