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[中药多糖防治酒精性肝病作用机制的研究进展]

[Research progress in mechanisms of traditional Chinese medicine polysaccharides in prevention and treatment of alcoholic liver disease].

作者信息

Chen Yu-Fan, Jiang He, Ma Qing, Luo Qi-Han, Huang Shuo, Qiu Jiang, Chen Fu-Zhe, Shan Zi-Yi, Qiu Ping

机构信息

the Second School of Clinical Medicine, Zhejiang Chinese Medical University Hangzhou 310053, China School of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou 310053, China.

the Second School of Clinical Medicine, Zhejiang Chinese Medical University Hangzhou 310053, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2025 Jan;50(2):356-362. doi: 10.19540/j.cnki.cjcmm.20240928.601.


DOI:10.19540/j.cnki.cjcmm.20240928.601
PMID:39929617
Abstract

Alcoholic liver disease(ALD), a major cause of chronic liver disease worldwide, poses a serious threat to human health. Despite the availability of various drugs for treating ALD, their efficacy is often uncertain, necessitating the search for new therapeutic approaches. Traditional Chinese medicine polysaccharides have garnered increasing attention in recent years due to their versatility, high efficiency, and low side effects, and they have demonstrated significant potential in preventing and treating ALD. Emerging studies have suggested that these polysaccharides exert their therapeutic effects through multiple mechanisms, including the inhibition of oxidative stress and the regulation of lipid metabolism, gut microbiota, and programmed cell death. This review summarizes the recent research progress in the pharmacological effects and regulatory mechanisms of traditional Chinese medicine polysaccharides in treating ALD, aiming to provide a scientific basis and theoretical support for their application in the prevention and treatment of ALD.

摘要

酒精性肝病(ALD)是全球慢性肝病的主要病因,对人类健康构成严重威胁。尽管有多种治疗ALD的药物,但它们的疗效往往不确定,因此需要寻找新的治疗方法。近年来,中药多糖因其多功能性、高效性和低副作用而受到越来越多的关注,并且在预防和治疗ALD方面显示出巨大潜力。新兴研究表明,这些多糖通过多种机制发挥治疗作用,包括抑制氧化应激以及调节脂质代谢、肠道微生物群和程序性细胞死亡。本综述总结了中药多糖治疗ALD的药理作用和调节机制的最新研究进展,旨在为其在ALD预防和治疗中的应用提供科学依据和理论支持。

相似文献

[1]
[Research progress in mechanisms of traditional Chinese medicine polysaccharides in prevention and treatment of alcoholic liver disease].

Zhongguo Zhong Yao Za Zhi. 2025-1

[2]
Targeting regulation of lipid metabolism with polysaccharide of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease: A review.

Int J Biol Macromol. 2025-5

[3]
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[4]
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[5]
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[6]
Qiwei Jinggan Ling regulates oxidative stress and lipid metabolism in alcoholic liver disease by activating AMPK.

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[7]
Effects of traditional Chinese medicine polysaccharides on chronic diseases by modulating gut microbiota: A review.

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[8]
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[9]
Therapeutic manipulation of gut microbiota by polysaccharides of reveals the contribution of the gut fungi-induced PGE to alcoholic hepatic steatosis.

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[10]
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