Yoshimoto Ayano, Nunobiki Sarika, Ito Makiko, Yonoichi Sakura, Hara Yukako, Ishida Yuya, Mantani Youhei, Yokoyama Toshifumi, Hirano Tetsushi, Ikenaka Yoshinori, Hoshi Nobuhiko
Laboratory of Animal Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University, Hyogo, Japan.
J Vet Med Sci. 2025 Apr 1;87(4):419-425. doi: 10.1292/jvms.24-0531. Epub 2025 Feb 13.
Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN's adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. We orally administered FPN (0.43 mg/kg) to 4-week-old male mice for 6 wk and assessed their behavior and blood characteristics. Compared with the control group, the FPN-treated group presented reduced weight gain but upward trends in locomotor activity and blood histamine levels. Fipronil sulfone (FPNS) was detected in all individuals, whereas FPN was not detected in any individual. The present study shows for the first time that subchronic exposure to low-dose FPN in mice led to FPNS conversion in the body, affecting weight gain and behavior.
氟虫腈（FPN）可抑制A型γ-氨基丁酸受体并表现出强烈的杀虫效果。尽管近期已有关于FPN对哺乳动物产生不良影响的报道，但很少有研究探讨低剂量亚慢性暴露的情况。我们对4周龄雄性小鼠口服给予FPN（0.43毫克/千克），持续6周，并评估它们的行为和血液特征。与对照组相比，FPN处理组的体重增加减少，但运动活动和血液组胺水平呈上升趋势。在所有个体中均检测到氟虫腈砜（FPNS），而在任何个体中均未检测到FPN。本研究首次表明，小鼠低剂量亚慢性暴露于FPN会导致体内发生FPNS转化，影响体重增加和行为。
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