Knight M, Ebert J, Parish R A, Berry H, Fogelson M H
Arch Neurol. 1985 May;42(5):474-5. doi: 10.1001/archneur.1985.04060050076011.
Previous studies have suggested that levels of cerebrospinal fluid (CSF) gamma-aminobutyric acid (GABA) may be decreased in children with febrile seizures. We used gas chromatography and mass spectrometry to measure CSF GABA levels in 14 children with febrile seizures. The results were compared with the GABA levels in six children with first-time afebrile seizures, three with recurrent febrile seizures, and 13 controls (febrile children undergoing lumbar puncture to rule out meningitis). Children with central nervous system infections or known neurologic disease were excluded. The CSF GABA levels in children with febrile seizures were not significantly different from those in controls and children with afebrile or recurrent febrile seizures. In the control group, CSF GABA levels correlated with increasing age. There was no correlation with severity of febrile response in any group. The results indicated that the CSF GABA level may not be abnormal in patients with first-time febrile convulsions.
先前的研究表明，热性惊厥患儿的脑脊液（CSF）γ-氨基丁酸（GABA）水平可能会降低。我们使用气相色谱和质谱法测量了14例热性惊厥患儿的脑脊液GABA水平。将结果与6例首次无热惊厥患儿、3例复发性热性惊厥患儿以及13例对照（因发热接受腰椎穿刺以排除脑膜炎的患儿）的GABA水平进行了比较。排除了患有中枢神经系统感染或已知神经系统疾病的患儿。热性惊厥患儿的脑脊液GABA水平与对照组以及无热或复发性热性惊厥患儿的脑脊液GABA水平无显著差异。在对照组中，脑脊液GABA水平与年龄增长相关。在任何组中，均与发热反应的严重程度无关。结果表明，首次热性惊厥患者的脑脊液GABA水平可能并无异常。
