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经产妇剖宫产风险预测模型的开发与验证

Development and validation of a risk prediction model for caesarean delivery among multiparous women.

作者信息

Yimer Nigus Bililign, Mekonnen Eskedar Getie

机构信息

Department of Midwifery, College of Health Sciences, Woldia University, Woldia, Ethiopia.

School of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

出版信息

Sci Rep. 2025 Feb 13;15(1):5326. doi: 10.1038/s41598-025-86015-w.

Abstract

While caesarean risk prediction models exist for nulliparous and high-risk pregnancies, there is a lack of models that predict the risk of caesarean delivery among multiparous women. This study aimed to develop and validate a risk prediction model for caesarean delivery and assess its clinical utility among multiparous women. Using data from 460 participants, a prediction model was developed to predict the risk of caesarean delivery. The model performance was evaluated using the area under the receiver operating characteristic curve (AUC) and calibration plot, and the model was internally validated using bootstrapping technique. A simplified risk score was calculated, and a nomogram was developed for the individual caesarean delivery risk guide. Additionally, a decision curve analysis was performed to assess the clinical utility of the model. The final model included four predictors: maternal age, previous caesarean delivery, pregnancy-induced hypertension, and antepartum hemorrhage. The model had an AUC of 78.0% (95% CI 71.1-84.8), indicating good discrimination capacity. The model also exhibited good calibration and a low overoptimism coefficient, indicating minimal risk of overfitting. The risk prediction model has good clinical utility for discriminating multiparous women at risk of caesarean delivery. The tool can guide clinicians in estimating the risk of caesarean delivery among multiparous women that could lead to improved maternal and neonatal outcomes, ultimately enhancing the quality of care delivered in low-resource settings.

摘要

虽然存在针对初产妇和高危妊娠的剖宫产风险预测模型,但缺乏预测经产妇剖宫产风险的模型。本研究旨在开发并验证一种剖宫产风险预测模型,并评估其在经产妇中的临床应用价值。利用460名参与者的数据,开发了一个预测模型来预测剖宫产风险。使用受试者工作特征曲线下面积(AUC)和校准图评估模型性能,并使用自抽样技术对模型进行内部验证。计算了简化风险评分,并绘制了列线图以指导个体剖宫产风险评估。此外,进行了决策曲线分析以评估模型的临床应用价值。最终模型包括四个预测因素:产妇年龄、既往剖宫产史、妊娠期高血压和产前出血。该模型的AUC为78.0%(95%CI 71.1-84.8),表明具有良好的区分能力。该模型还表现出良好的校准和较低的过度乐观系数,表明过拟合风险最小。该风险预测模型在区分有剖宫产风险的经产妇方面具有良好的临床应用价值。该工具可指导临床医生评估经产妇的剖宫产风险,这可能会改善孕产妇和新生儿结局,最终提高资源匮乏地区的医疗服务质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/46f7/11825932/9d7fd790bbd9/41598_2025_86015_Fig1_HTML.jpg

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