Haghighatafshar Mahdi, Shekasteband Behnaz, Firuzyar Tahereh, Etemadi Zahra, Farhoudi Farinaz, Shams Mesbah
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Iran J Med Sci. 2025 Jan 1;50(1):31-36. doi: 10.30476/ijms.2024.101112.3372. eCollection 2025 Jan.
The impact of low levels of vitamin D (Vit D) on the severity of cardiovascular diseases has become a significant challenge. This study aimed to assess this impact.
This pilot cross-sectional study enrolled two hundred patients referred to Namazi Hospital, Shiraz, Iran for myocardial perfusion imaging in 2019. The assessment included myocardial perfusion imaging and Vit D level evaluation. Quantitative ischemia analysis utilized Estimated Summed Stress Scores (SSS), Summed Rest Scores (SRS), and Summed Difference Scores (SDS). Myocardial Perfusion Imaging (MPI) results were categorized into normal, mild ischemia, moderate ischemia, and severe ischemia based on estimated SSS. Ischemia severity was aligned with established criteria, designating severe quantitative ischemia as SSS>13. Vit D was categorized using cutoffs at 10, 20, and 30 ng/mL. Mann-Whitney U-test was used for quantitative variables and Chi Square test for qualitative variables.
Chi Square test revealed a significant association between categorized Vit D levels below 10 ng/mL and severe ischemia (SSS>13) (P<0.001). Total Vit D level and also categorized Vit D with cut-offs of 10, 20, and 30 ng/mL showed no association with abnormal MPI. SSS was notably higher in patients with Vit D levels below 10 ng/mL (P=0.026).
The findings of this study emphasize an association between Vit D level below 10 ng/mL and severe myocardial ischemia, as indicated by SSS.
低水平维生素D（Vit D）对心血管疾病严重程度的影响已成为一项重大挑战。本研究旨在评估这种影响。
这项前瞻性横断面研究纳入了2019年转诊至伊朗设拉子纳马齐医院进行心肌灌注显像的200例患者。评估包括心肌灌注显像和Vit D水平评估。定量缺血分析采用估计的总应激评分（SSS）、总静息评分（SRS）和总差异评分（SDS）。根据估计的SSS，将心肌灌注显像（MPI）结果分为正常、轻度缺血、中度缺血和重度缺血。缺血严重程度根据既定标准确定，将严重定量缺血定义为SSS>13。Vit D根据10、20和30 ng/mL的临界值进行分类。对定量变量采用曼-惠特尼U检验，对定性变量采用卡方检验。
卡方检验显示，Vit D水平低于10 ng/mL与严重缺血（SSS>13）之间存在显著关联（P<0.001）。总Vit D水平以及临界值为10、20和30 ng/mL的分类Vit D与异常MPI均无关联。Vit D水平低于10 ng/mL的患者SSS显著更高（P=0.026）。
本研究结果强调，SSS显示Vit D水平低于10 ng/mL与严重心肌缺血之间存在关联。
