Countouris Malamo, Mahmoud Zainab, Cohen Jordana B, Crousillat Daniela, Hameed Afshan B, Harrington Colleen M, Hauspurg Alisse, Honigberg Michael C, Lewey Jennifer, Lindley Kathryn, McLaughlin Megan M, Sachdev Neha, Sarma Amy, Shapero Kayle, Sinkey Rachel, Tita Alan, Wong Kristen E, Yang Eugene, Cho Leslie, Bello Natalie A
Department of Medicine, Division of Cardiology (M.C.), PA.
Department of Medicine, Division of Cardiology, Washington University in St Louis, MO (Z.M., K.E.W.).
Circulation. 2025 Feb 18;151(7):490-507. doi: 10.1161/CIRCULATIONAHA.124.073302. Epub 2025 Feb 17.
Hypertension in pregnancy contributes substantially to maternal morbidity and mortality, persistent hypertension, and rehospitalization. Hypertensive disorders of pregnancy are also associated with a heightened risk of cardiovascular disease, and timely recognition and modification of associated risk factors is crucial in optimizing long-term maternal health. During pregnancy, there are expected physiologic alterations in blood pressure (BP); however, pathophysiologic alterations may also occur, leading to preeclampsia and gestational hypertension. The diagnosis and effective management of hypertension during pregnancy is essential to mitigate maternal risks, such as acute kidney injury, stroke, and heart failure, while balancing potential fetal risks, such as growth restriction and preterm birth due to altered uteroplacental perfusion. In the postpartum period, innovative and multidisciplinary care solutions that include postpartum maternal health clinics can help optimize short- and long-term care through enhanced BP management, screening of cardiovascular risk factors, and discussion of lifestyle modifications for cardiovascular disease prevention. As an adjunct to or distinct from postpartum clinics, home BP monitoring programs have been shown to improve BP ascertainment across diverse populations and to lower BP in the months after delivery. Because of concerns about pregnant patients being a vulnerable population for research, there is little evidence from trials examining the diagnosis and treatment of hypertension in pregnant and postpartum individuals. As a result, national and international guidelines differ in their recommendations, and more studies are needed to bolster future guidelines and establish best practices to achieve optimal cardiovascular health during and after pregnancy. Future research should focus on refining treatment thresholds and optimal BP range peripartum and postpartum and evaluating interventions to improve postpartum and long-term maternal cardiovascular outcomes that would advance evidence-based care and improve outcomes worldwide for people with hypertensive disorders of pregnancy.
妊娠期高血压在很大程度上导致孕产妇发病和死亡、持续性高血压及再次住院。妊娠期高血压疾病还与心血管疾病风险增加相关,及时识别并改变相关风险因素对于优化孕产妇长期健康至关重要。孕期血压(BP)会出现预期的生理变化;然而,也可能发生病理生理变化,导致子痫前期和妊娠期高血压。妊娠期高血压的诊断和有效管理对于降低孕产妇风险(如急性肾损伤、中风和心力衰竭)至关重要,同时要平衡潜在的胎儿风险,如因子宫胎盘灌注改变导致的生长受限和早产。在产后阶段,包括产后孕产妇健康诊所在内的创新多学科护理方案可通过加强血压管理、筛查心血管风险因素以及讨论预防心血管疾病的生活方式改变,帮助优化短期和长期护理。作为产后诊所的补充或与之不同,家庭血压监测项目已被证明可改善不同人群的血压测定,并在分娩后的几个月内降低血压。由于担心孕妇是研究的弱势群体,几乎没有来自试验的证据来检验妊娠和产后个体高血压的诊断和治疗。因此,国家和国际指南的建议存在差异,需要更多研究来支持未来的指南并确立最佳实践,以在孕期及产后实现最佳心血管健康。未来的研究应侧重于完善围产期和产后的治疗阈值及最佳血压范围,并评估改善产后及长期孕产妇心血管结局的干预措施,这将推动循证护理并改善全球患有妊娠期高血压疾病人群的结局。