[具有祛痰活性的半胱氨酸和胱氨酸衍生物的新型2,4-二溴-6-(N-环己基-N-甲基)氨基甲基苯胺]
[New 2,4-dibromo-6-(N-cyclohexyl-N-methyl)-aminomethylanilides of derivatives of cysteine and cystine with expectorant activity].
作者信息
Nardi D, Motta G, Tajana A, Catto A, Cazzulani P, Leonardi A
出版信息
Farmaco Sci. 1985 Feb;40(2):108-19.
PMID:3996580
Abstract
New 2,4-dibromo-6-(N-cyclohexyl-N-methyl)aminomethylanilides of N-acetylcysteine and N-acetyl-S-carboxymethylcisteine derivatives, N-benzyloxycarbonylcysteine and N,N'-bisbenzyloxycarbonylcystine were synthesized. The compounds were tested for the expectorant activity in rabbit and mouse. N,N'-Bisbenzyloxycarbonylcystin-bis [2,4-dibromo-6-(N-cyclohexyl-N-methyl)aminomethyl]anilide (XIX) was selected for further investigations.
摘要
合成了N-乙酰半胱氨酸和N-乙酰-S-羧甲基半胱氨酸衍生物、N-苄氧羰基半胱氨酸以及N,N'-双苄氧羰基胱氨酸的新型2,4-二溴-6-(N-环己基-N-甲基)氨基甲基苯胺。对这些化合物在兔和小鼠体内进行了祛痰活性测试。选择N,N'-双苄氧羰基胱氨酸-双[2,4-二溴-6-(N-环己基-N-甲基)氨基甲基]苯胺（XIX）进行进一步研究。
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