具有降压活性的N-取代的4,7,7-三甲基-3-(1-哌啶基)双环-[2.2.1]庚-2-烯-2-甲酰胺和2-硫代甲酰胺
N-substituted 4,7,7-trimethyl-3-(1-piperidinyl)bicyclo-[2.2.1]hept-2-ene 2-carboxamides and 2-carbothioamides with hypotensive activity.
作者信息
Ranise A, Bondavalli F, Schenone P, Berrino L, Matera C, Persico N, Romano A R, Marmo E
出版信息
Farmaco Sci. 1985 Feb;40(2):120-3.
The synthesis of two series of N-substituted 4,7,7-trimethyl-3-(1-piperidinyl)bicyclo[2.2.1]hept-2-ene 2-carboxamides (I d-h) and 2-carbothioamides (I i-o), as well as of some N-aryl 4,7,7-trimethyl-3-(1-pyrrolidinyl)bicyclo[2.2.1]hept-2-ene 2-carboxamides (I a-c), by reaction of camphor piperidinoenamine and pyrrolidinoenamine with aryl isocyanates and isothiocyanates is described. On the whole compounds (I d-h) showed a weak hypotensive activity in rats.
描述了通过樟脑哌啶烯胺和吡咯烷烯胺与芳基异氰酸酯和异硫氰酸酯反应合成两个系列的N-取代的4,7,7-三甲基-3-(1-哌啶基)双环[2.2.1]庚-2-烯-2-甲酰胺（I d-h）和2-硫代甲酰胺（I i-o），以及一些N-芳基4,7,7-三甲基-3-(1-吡咯烷基)双环[2.2.1]庚-2-烯-2-甲酰胺（I a-c）。总体而言，化合物（I d-h）在大鼠中显示出较弱的降压活性。
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