Oe Shinji, Nakamura Koichi, Shinohara Nobuhiko, Uchihara Daiki, Miyagawa Koichiro, Tsukamoto Teppei, Mori Yasuhisa, Harada Masaru
Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan.
Intern Med. 2025 Aug 15;64(16):2433-2438. doi: 10.2169/internalmedicine.4996-24. Epub 2025 Feb 18.
Mixed neuroendocrine-non-neuroendocrine neoplasm of the gallbladder (GB-MiNEN) is an exceptionally rare and aggressive tumor with no established treatment guidelines. We herein present the case of a 53-year-old woman with GB-MiNEN who was treated with irinotecan and cisplatin therapy, which led to a significant tumor reduction and subsequent conversion surgery. Despite a later recurrence, multimodal therapy extended survival for over two and a half years. This case underscores the potential benefit of conversion surgery combined with systemic chemotherapy, thus suggesting that multimodal treatment may improve the outcomes of GB-MiNEN. Our findings highlight the need for further studies to optimize the treatment strategies for this rare malignancy.
胆囊混合性神经内分泌-非神经内分泌肿瘤（GB-MiNEN）是一种极其罕见且侵袭性强的肿瘤，目前尚无既定的治疗指南。我们在此报告一例53岁患有GB-MiNEN的女性病例，该患者接受了伊立替康和顺铂治疗，肿瘤显著缩小，随后接受了转化手术。尽管后来复发，但多模式治疗使患者生存期延长了两年半以上。该病例强调了转化手术联合全身化疗的潜在益处，表明多模式治疗可能改善GB-MiNEN的治疗效果。我们的研究结果凸显了进一步研究以优化这种罕见恶性肿瘤治疗策略的必要性。
