哺乳动物细胞中的细胞周期调控：激素与DNA合成的启动
Cell cycle regulation in mammalian cells: hormones and commitment to DNA synthesis.
作者信息
Armelin H A, Armelin M C
出版信息
Arch Biol Med Exp. 1979 Oct;12(3):319-24.
PMID:399721
Abstract
The growth regulation of cultured mouse fibroblasts and functional adrenal cells was studied. Variants of mutants from these cell lines were obtained. The effects of classical hormones (insulin, hydrocortisone and adrenocorticotropin) and of growth factors (EGF and PF) were analysed. These hormones stimulate or inhibit the entry of cells into S phase. However G1 cells become irreversibly committed to DNA synthesis 5 hours before entering S phase.
摘要
对培养的小鼠成纤维细胞和功能性肾上腺细胞的生长调节进行了研究。获得了这些细胞系突变体的变体。分析了经典激素（胰岛素、氢化可的松和促肾上腺皮质激素）和生长因子（表皮生长因子和血小板衍生因子）的作用。这些激素刺激或抑制细胞进入S期。然而，G1期细胞在进入S期前5小时就不可逆转地进入DNA合成阶段。
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