CD56在脾脏组织病理学中的表达及其在1型糖尿病发病中的意义：来自糖尿病大鼠模型的见解
CD56 Expression in Spleen Tissue Pathology and Its Implications in the Development of Type 1 Diabetes: Insights from Diabetic Rat Models.
作者信息
Ababneh Suha Khayri, Odat Osama, Alsarhan Ali Ata, Al-Shawabkeh Jumanah D, Al-Rawashde Futoon Abedrabbu, Al-Jaloudi Rawan, Alqaraleh Moath, Al-Othman Nihad, Alkhatib Ahed J
机构信息
Department of Allied Medical Sciences Zarqa University College Al-Balqa Applied University Zarqa Jordan.
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan.
出版信息
Med Arch. 2024;78(4):274-278. doi: 10.5455/medarh.2024.78.274-278.
BACKGROUND
Type 1 diabetes (T1D) is an autoimmune disease characterized by the destruction of beta cells in the pancreas.
OBJECTIVE
This study's goals were to look at how much CD56 was expressed in the spleen tissue of rats with type 1 diabetes and compare it to rats that were not diabetic.
METHODS
The method used in this study was to give rats type 1 diabetes by giving them Alloxan (120 mg/kg). The rats had diabetes for one month. As soon as the experiment was over, all the animals were put down and prepared for normal biochemical, histology, and immunohistochemical tests.
RESULTS
The study results revealed that the biochemical findings including glucose, cholesterol, and triglycerides in diabetic group were more significantly higher than that in the control group. The spleen tissue of diabetic rats was more inflamed than that of the control group, as shown by histological results. CD56 expression was much lower in the rats of diabetic group compared to the rats in the control group.
CONCLUSION
When looked at as a whole, CD56's role in diabetes seems to have been lost. This explains why people with type 1 diabetes have inflammatory problems.
背景
1型糖尿病（T1D）是一种自身免疫性疾病，其特征是胰腺中的β细胞被破坏。
目的
本研究的目的是观察1型糖尿病大鼠脾脏组织中CD56的表达量，并将其与非糖尿病大鼠进行比较。
方法
本研究采用的方法是给大鼠注射四氧嘧啶（120mg/kg）使其患1型糖尿病。大鼠患糖尿病1个月。实验一结束，所有动物均被处死，并准备进行常规生化、组织学和免疫组织化学检测。
结果
研究结果显示，糖尿病组的血糖、胆固醇和甘油三酯等生化指标显著高于对照组。组织学结果表明，糖尿病大鼠的脾脏组织比对照组更发炎。与对照组大鼠相比，糖尿病组大鼠的CD56表达量要低得多。
结论
总体来看，CD56在糖尿病中的作用似乎已经丧失。这就解释了为什么1型糖尿病患者会出现炎症问题。
Zotero 插件