一名溃疡性结肠炎患者在药物假期后发生维多珠单抗输注过敏反应：病例报告
Anaphylaxis to a Vedolizumab Infusion following Drug Holiday in a Patient with Ulcerative Colitis: A Case Report.
作者信息
Karp Jadon, Shen Henry, Goodwin Thomas, Sparrow Miles P
机构信息
Department of Gastroenterology, The Alfred Hospital, Melbourne, VIC, Australia.
School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
出版信息
Case Rep Gastroenterol. 2025 Feb 12;19(1):62-66. doi: 10.1159/000543387. eCollection 2025 Jan-Dec.
INTRODUCTION
Vedolizumab is a commonly prescribed biologic agent due to its safety profile and clinical efficacy. Severe infusion-related reactions are exceedingly rare, with no previously documented cases of anaphylaxis to vedolizumab infusion following a drug holiday.
CASE PRESENTATION
We report the case of a 65-year-old male with ulcerative colitis who had a severe anaphylactic reaction to the first re-induction infusion of vedolizumab following a 30-month drug holiday. No pre-infusion prophylactic medication was administered. Upon commencement of the infusion, the patient developed anaphylactic symptoms including airway compromise that required intensive care unit admission and treatment with an adrenaline infusion.
CONCLUSION
Anaphylactic reactions to vedolizumab after a drug holiday can occur. As is done for infliximab, we recommend administration of an antipyretic, antihistamine, and corticosteroid prior to vedolizumab re-induction infusions when it is given after a drug holiday.
引言
维多珠单抗因其安全性和临床疗效而成为常用的生物制剂。严重的输液相关反应极为罕见，此前尚无药物假期后维多珠单抗输液发生过敏反应的记录病例。
病例报告
我们报告一例65岁溃疡性结肠炎男性患者，在30个月的药物假期后，首次重新诱导输注维多珠单抗时发生严重过敏反应。未给予输液前预防性用药。输液开始后，患者出现过敏症状，包括气道受损，需要入住重症监护病房并接受肾上腺素输注治疗。
结论
药物假期后维多珠单抗可发生过敏反应。与英夫利昔单抗一样，我们建议在药物假期后重新诱导输注维多珠单抗前给予退烧药、抗组胺药和皮质类固醇。
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