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童年经历过逆境的个体,其间脑耦合异常可能是他们难以从社交互动中获益的潜在原因。

Abnormal interbrain coupling in individuals with childhood adversity may underlie their difficulties in benefiting from social interactions.

作者信息

Avnor Yarden, Shamay-Tsoory Simone

机构信息

Department of Psychology, University of Haifa, Israel.

Department of Psychology, University of Haifa, Israel; The Integrated Brain and Behavior Research Center (IBBRC), Israel.

出版信息

J Affect Disord. 2025 May 15;377:206-216. doi: 10.1016/j.jad.2025.02.050. Epub 2025 Feb 20.

Abstract

BACKGROUND

While adverse childhood experiences (ACEs) such as abuse or neglect are linked to lifelong interpersonal challenges, it's uncertain whether individuals with ACEs can effectively draw on others for distress relief and whether neural dyadic processes in these exchanges are compromised.

METHOD

To address this gap, here we examined interbrain coupling between 'targets' (adults with a varying history of ACEs) and 'regulators' (unacquainted individuals without a history of ACEs) during two conditions: (i) distressing condition: where the target shares with the regulator a distressing biographical event; (ii) neutral condition: where the target shares with the regulator a neutral biographical event. After screening 534 participants, 58 dyads were simultaneously scanned with functional near-infrared spectroscopy (fNIRS), during the distress/neutral conditions to investigate interbrain coupling in the dorsolateral pre-frontal cortex (DLPFC), a core region of the emotion regulation network.

RESULTS

Consistent with our hypothesis that individuals with high ACEs have difficulty relying on social support, we observed a significant negative relationship between targets' cumulative ACEs and distress relief during the distressing condition. Neuroimaging revealed that higher ACEs scores were significantly linked to differential interbrain coupling patterns in the DLPFC: increased coupling during the distressing condition and decreased coupling during the neutral condition.

CONCLUSIONS

Among higher ACEs dyads, hyper interbrain coupling during distress may suggest heightened yet unsuccessful efforts to regulate distress, while hypo interbrain coupling in non-distressing situations may indicate poor connectedness in neutral social interactions. Therefore, abnormal interbrain coupling may underlie the difficulties high ACEs individuals face in benefiting from supportive interactions.

摘要

背景

虽然诸如虐待或忽视等童年不良经历(ACEs)与终身人际挑战相关,但尚不确定有ACEs经历的个体能否有效地借助他人缓解痛苦,以及这些交流中的神经二元过程是否受损。

方法

为了填补这一空白,我们在此研究了“目标者”(有不同ACEs经历的成年人)和“调节者”(无ACEs经历的陌生个体)在两种情况下的脑间耦合:(i)痛苦情境:目标者与调节者分享一件痛苦的个人经历;(ii)中性情境:目标者与调节者分享一件中性的个人经历。在筛选了534名参与者后,58对组合在痛苦/中性情境中同时接受功能近红外光谱(fNIRS)扫描,以研究情绪调节网络的核心区域背外侧前额叶皮层(DLPFC)中的脑间耦合。

结果

与我们的假设一致,即有高ACEs经历的个体难以依赖社会支持,我们观察到在痛苦情境中,目标者累积的ACEs与痛苦缓解之间存在显著的负相关。神经影像学显示,较高的ACEs得分与DLPFC中不同的脑间耦合模式显著相关:在痛苦情境中耦合增加,在中性情境中耦合减少。

结论

在高ACEs得分的组合中,痛苦时脑间耦合增强可能表明调节痛苦的努力增强但未成功,而非痛苦情境下脑间耦合减弱可能表明中性社会互动中的联系不佳。因此,异常的脑间耦合可能是高ACEs个体在从支持性互动中获益时面临困难的潜在原因。

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