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关于长期新冠干预措施对脑雾、处理速度及其他相关认知结果疗效的叙述性综述。

A Narrative Review of the Efficacy of Long COVID Interventions on Brain Fog, Processing Speed, and Other Related Cognitive Outcomes.

作者信息

Whitaker-Hardin Bryana, McGregor Keith M, Uswatte Gitendra, Lokken Kristine

机构信息

Neuroscience Theme, Graduate Biomedical Sciences Doctoral Training Program, Joint Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Birmingham Veterans Affairs Geriatric Research Education and Clinical Center, Birmingham Veterans Affairs Health Care System, Birmingham, AL 35294, USA.

出版信息

Biomedicines. 2025 Feb 10;13(2):421. doi: 10.3390/biomedicines13020421.

Abstract

In the years following the global emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or COVID-19, researchers have become acutely aware of long-term symptomology associated with this disease, often termed long COVID. Long COVID is associated with pervasive symptoms affecting multiple organ systems. Neurocognitive symptoms are reported by up to 40% of long COVID patients, with resultant effects of loss of daily functioning, employment issues, and enormous economic impact and high healthcare utilization. The literature on effective, safe, and non-invasive interventions for the remediation of the cognitive consequences of long COVID is scarce and poorly described. Of specific interest to this narrative review is the identification of potential interventions for long COVID-associated neurocognitive deficits. Articles were sourced from PubMed, EBSCO, Scopus, and Embase following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Articles published between the dates of January 2020 and 30 June 2024 were included in the search. Twelve studies were included in the narrative review, including a feasibility study, a pilot study, a case series, a case study, and an observational study, in addition to three randomized clinical trials and four interventional studies. Overall, treatment interventions such as cognitive training, non-invasive brain stimulation therapy, exercise rehabilitation, targeted pharmacological intervention, and other related treatment paradigms show promise in reducing long COVID cognitive issues. This narrative review highlights the need for more rigorous experimental designs and future studies are needed to fully evaluate treatment interventions for persistent cognitive deficits associated with long COVID.

摘要

在严重急性呼吸综合征冠状病毒2(SARS-CoV-2),即新冠病毒病(COVID-19)在全球出现后的几年里,研究人员已经敏锐地意识到与这种疾病相关的长期症状,通常称为“长新冠”。“长新冠”与影响多个器官系统的普遍症状有关。高达40%的“长新冠”患者报告有神经认知症状,导致日常功能丧失、就业问题,以及巨大的经济影响和高医疗利用率。关于有效、安全且无创的干预措施以改善“长新冠”认知后果的文献很少且描述不佳。本叙述性综述特别感兴趣的是确定针对“长新冠”相关神经认知缺陷的潜在干预措施。文章来源为遵循系统评价和荟萃分析首选报告项目(PRISMA)指南的PubMed、EBSCO、Scopus和Embase。搜索纳入了2020年1月至2024年6月30日期间发表的文章。本叙述性综述纳入了12项研究,除了三项随机临床试验和四项干预性研究外,还包括一项可行性研究、一项试点研究、一个病例系列、一个病例研究和一项观察性研究。总体而言,认知训练、无创脑刺激疗法、运动康复、靶向药物干预等治疗干预措施以及其他相关治疗模式在减少“长新冠”认知问题方面显示出前景。本叙述性综述强调需要更严谨的实验设计,并且需要未来的研究来全面评估针对与“长新冠”相关的持续性认知缺陷的治疗干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9789/11853337/b01e68e03767/biomedicines-13-00421-g001.jpg

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