Chen Humin, Guo Liang
School of Exercise and Health and Collaborative Innovation Center for Sports and Public Health, Shanghai University of Sport, Shanghai 200438, China.
Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
Int J Mol Sci. 2025 Feb 10;26(4):1465. doi: 10.3390/ijms26041465.
Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes, characterized by the development of ventricular systolic and diastolic dysfunction due to factors such as inflammation, oxidative stress, fibrosis, and disordered glucose metabolism. As a sustainable therapeutic approach, exercise has been reported in numerous studies to regulate blood glucose and improve abnormal energy metabolism through various mechanisms, thereby ameliorating left ventricular diastolic dysfunction and mitigating DCM. This review summarizes the positive impacts of exercise on DCM and explores its underlying molecular mechanisms, providing new insights and paving the way for the development of tailored exercise programs for the prophylaxis and therapy of DCM.
糖尿病性心肌病（DCM）是糖尿病的心血管并发症之一，其特征是由于炎症、氧化应激、纤维化和糖代谢紊乱等因素导致心室收缩和舒张功能障碍。作为一种可持续的治疗方法，众多研究报告称运动可通过多种机制调节血糖并改善异常的能量代谢，从而改善左心室舒张功能障碍并减轻DCM。本综述总结了运动对DCM的积极影响，并探讨其潜在的分子机制，为开发针对DCM预防和治疗的个性化运动方案提供新见解并铺平道路。
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